UC168
(±)-Bufuralol hydrochloride
≥98% (HPLC), solid, β-Adrenoceptor agonist/antagonist
동의어(들):
α-[(tert-Butylamino)methyl]-7-ethyl-2-benzofuranmethanol hydrochloride
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모든 사진(1)
About This Item
실험식(Hill 표기법):
C16H23NO2·HCl
CAS Number:
Molecular Weight:
297.82
EC Number:
MDL number:
UNSPSC 코드:
12161501
PubChem Substance ID:
NACRES:
NA.77
추천 제품
제품명
(±)-Bufuralol hydrochloride,
양식
solid
색상
white to off-white
mp
143-146 °C
solubility
H2O: soluble
methanol: soluble
저장 온도
2-8°C
SMILES string
Cl.CCc1cccc2cc(oc12)C(O)CNC(C)(C)C
InChI
1S/C16H23NO2.ClH/c1-5-11-7-6-8-12-9-14(19-15(11)12)13(18)10-17-16(2,3)4;/h6-9,13,17-18H,5,10H2,1-4H3;1H
InChI key
KJBONRGCLLBWCJ-UHFFFAOYSA-N
관련 카테고리
애플리케이션
CYP2D6 substrate
생화학적/생리학적 작용
β-Blocker. Varying β-adrenoceptor agonist/antagonist activity.
Bufuralol hydrochloride is known to be a non-specific β-receptor inhibitor that has an affinity for β 1 and β 2 receptors. Furthermore, studies have reported that bufuralol hydrochloride can decrease isoproterenol peripheral resistance.
특징 및 장점
This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
포장
Bottomless glass bottle. Contents are inside inserted fused cone.
제조 메모
(±)-Bufuralol hydrochloride is soluble in water and methanol.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
개인 보호 장비
dust mask type N95 (US), Eyeshields, Gloves
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시험 성적서(COA)
Lot/Batch Number
Sami Haddad et al.
Journal of pharmaceutical sciences, 99(10), 4406-4426 (2010-03-24)
Drug-drug interactions (DDIs) are a great concern to the selection of new drug candidates. While in vitro screening assays for DDI are a routine procedure in preclinical research, their interpretation and relevance for the in vivo situation still represent a
Nina Nordman et al.
Journal of chromatography. A, 1218(5), 739-745 (2010-12-28)
Monolithically integrated, polymer (SU-8) microchips comprising an electrophoretic separation unit, a sheath flow interface, and an electrospray ionization (ESI) emitter were developed to improve the speed and throughput of metabolism research. Validation of the microchip method was performed using bufuralol
S S Shah et al.
Journal of veterinary pharmacology and therapeutics, 30(5), 422-428 (2007-09-07)
In this study we examined activities of cytochrome P450 (CYP)1A, 2C, 2D and 3A using hepatic microsomes from five male and five female cats. CYP1A, 2C, 2D and 3A activities were referred by ethoxyresorufin O-deethylation (EROD), tolbutamide hydroxylation (TBH), bufuralol
Evangelos P Daskalopoulos et al.
Molecular pharmacology, 82(4), 668-678 (2012-07-10)
Various hormonal and monoaminergic systems play determinant roles in the regulation of several cytochromes P450 (P450s) in the liver. Growth hormone (GH), prolactin, and insulin are involved in P450 regulation, and their release is under dopaminergic control. This study focused
Alois Bonifacio et al.
Biochemical and biophysical research communications, 343(3), 772-779 (2006-03-28)
Cytochrome P450 2D6 (CYP2D6) is one of the most important drug-metabolizing enzymes in humans. Resonance Raman data, reported for the first time for CYP2D6, show that the CYP2D6 heme is found to be in a six-coordinated low-spin state in the
관련 콘텐츠
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