U3885

UK-78282 monohydrochloride

≥98% (HPLC)

• 동의어(들): 4-[(Diphenylmethoxy)methyl]-1-[3-(4-methoxyphenyl)propyl]-piperidine monohydrochloride
• 실험식(Hill 표기법): C₂₉H₃₅NO₂HCl
• CAS Number: 136647-02-4
• Molecular Weight: 466.05
• MDL number: MFCD16875438
• UNSPSC 코드: 12352200
• PubChem Substance ID: 329827628
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥98% (HPLC)
• 양식: solid
• 저장 조건: desiccated
• 색상: white to off-white
• solubility: DMSO: >10 mg/mL
• 배송 상태: wet ice
• 저장 온도: −20°C
• SMILES string: Cl.COc1ccc(CCCN2CCC(CC2)COC(c3ccccc3)c4ccccc4)cc1
• InChI: 1S/C29H35NO2.ClH/c1-31-28-16-14-24(15-17-28)9-8-20-30-21-18-25(19-22-30)23-32-29(26-10-4-2-5-11-26)27-12-6-3-7-13-27;/h2-7,10-17,25,29H,8-9,18-23H2,1H3;1H
• InChI key: ZZSQARULZYQMIG-UHFFFAOYSA-N

설명

생화학적/생리학적 작용

UK-78282 blocks both Kv1.3 and Kv1.4. Kv1.3 and Kv1.4 are members of the Shaker family of voltage-gated potassium channels.

UK-78282 blocks both Kv1.3 and Kv1.4. Kv1.3 and Kv1.4 are members of the Shaker family of voltage-gated potassium channels. Kv1.3 is expressed in brain and in effector memory T (Tem) cells, and Kv1.4 is expressed in brain. Both channels are involved in setting the membrane potential of neurons. In addition, Kv1.3 maintains the membrane potential for T memory cells and is up-regulated upon T cell activation, contributing to multiple immune processes and disorders. Blockers of Kv1.3 have long been sought for therapeutic benefit, and they are also valuable tools for studying the immune system. Selective blockers of Kv1.4 are desired, as there are few if any currently available. UK-78282 is valuable for immune system studies, where the absence of Kv1.4 makes it functionally selective for Kv1.3, and it has shown suppression of T cell activation. UK-78282 is also valuable for the study of Kv1.4 function.

특징 및 장점

This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

제조 메모

UK-78282 monohydrochloride dissolves in DMSO at a concentration >10 mg/ml.

안전성 정보

• 픽토그램: GHS07,GHS09
• 신호어: Warning
• 유해 및 위험 성명서: H319,H400
• 예방조치 성명서: P264 - P273 - P280 - P305 + P351 + P338 - P337 + P313 - P391
• Hazard Classifications: Aquatic Acute 1 - Eye Irrit. 2
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable