T4680

Terazosin hydrochloride

≥98% (TLC), powder

• 동의어(들): 1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-[(tetrahydro-2-furanyl)carbonyl]piperazine hydrochloride
• 실험식(Hill 표기법): C₁₉H₂₅N₅O₄ · HCl
• CAS Number: 63074-08-8
• Molecular Weight: 423.89
• MDL number: MFCD00467965
• UNSPSC 코드: 12352200
• PubChem Substance ID: 24278740
• NACRES: NA.77

속성

• Quality Level: 200
• 분석: ≥98% (TLC)
• 형태: powder
• 색상: white to off-white
• solubility: H₂O: soluble 19.60-20.40 mg/mL, clear, colorless to faintly yellow; methanol: 20 mg/mL, clear, colorless; ethanol: 4 mg/mL
• 주관자: Abbott
• SMILES string: Cl[H].COc1cc2nc(nc(N)c2cc1OC)N3CCN(CC3)C(=O)C4CCCO4
• InChI: 1S/C19H25N5O4.ClH/c1-26-15-10-12-13(11-16(15)27-2)21-19(22-17(12)20)24-7-5-23(6-8-24)18(25)14-4-3-9-28-14;/h10-11,14H,3-9H2,1-2H3,(H2,20,21,22);1H
• InChI key: IWSWDOUXSCRCKW-UHFFFAOYSA-N
• 유전자 정보: human ... ADRA1A(148) , ADRA1B(147) , ADRA1D(146)

설명

일반 설명

Terazosin hydrochloride is used to treat hypertension and benign prostatic hyperplasia (BPH). It is metabolised in the liver. It might be associated with dizziness, headache and asthenia. Terazosin hydrochloride is linked to acute generalized exanthematous pustulosis.

애플리케이션

Terazosin hydrochloride has been used for orthogonality and similarity analysis using reversed-phase chromatographic studies⁵. Furthermore, terazosin has also been used for the evaluation of chemometric techniques to determine orthogonality and similarity in chromatographic methods⁶.

생화학적/생리학적 작용

α₁-adrenoceptor antagonist.

특징 및 장점

This compound was developed by Abbott. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

제조 메모

Terazosin hydrochloride is soluble in water at 19.60 - 20.40 mg/ml and yields a clear, colorless to faint yellow solution. It is also soluble in ethanol at 4 mg/ml. Furthermore, the product is soluble in methanol at 20 mg/ml, with heat as needed, and yields a clear, colorless solution.

안전성 정보

• 픽토그램: GHS07
• 신호어: Warning
• 유해 및 위험 성명서: H302
• 예방조치 성명서: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: dust mask type N95 (US), Eyeshields, Gloves