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Merck
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Key Documents

T3564

Sigma-Aldrich

Tumor Necrosis Factor Soluble Receptor I (TNF sRI) from mouse

>97% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

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About This Item

MDL number:
UNSPSC 코드:
51111800
NACRES:
NA.32

생물학적 소스

mouse

Quality Level

재조합

expressed in E. coli

분석

>97% (SDS-PAGE)

형태

lyophilized powder

효능

0.5-1.5 μg/mL ED50

분자량

21 kDa

포장

pkg of 50 μg

저장 조건

avoid repeated freeze/thaw cycles

기술

cell culture | mammalian: suitable

불순물

endotoxin, tested

UniProt 수납 번호

저장 온도

−20°C

유전자 정보

애플리케이션

Tumor Necrosis Factor Soluble Receptor I (TNF sRI) from mouse plays a pivotal role in the signaling of apoptosis and NF-κB activation because of its “death domain” present at the intracellular portion.

생화학적/생리학적 작용

Tumor Necrosis Factor Soluble Receptor I (TNF sRI) from mouse belongs to TNF family of receptors and has a pivotal role in neutralizing the biological activities of both TNF-α and TNF-β. Soluble tumor necrosis factor receptor along with intrathecal interleukin-1 receptor antagonist shows an anti-allodynic action in rat L5 spinal nerve transection model of neuropathic pain.

물리적 형태

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline with 2.5 mg bovine serum albumin

분석 메모

The biological activity is measured by its ability to inhibit the recombinant mouse TNF-α mediated cytotoxicity in mouse L929 cells, in the presence of the metabolic inhibitor actinomycin D.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable


시험 성적서(COA)

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문서 라이브러리 방문

S Sweitzer et al.
Neuroscience, 103(2), 529-539 (2001-03-14)
The expression of interleukin-1beta and tumor necrosis factor has previously been shown to be up-regulated in the spinal cord of several rat mononeuropathy models. This present study was undertaken to determine whether blocking the action of central interleukin-1beta and tumor
Matthews, N. et al. et al.
Lymphokines and Interferons, A Practical Approach, 221-221 (1987)

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