추천 제품
분석
≥85%
저장 온도
2-8°C
SMILES string
Cl[H].[H][C@@]12CC[C@]3([H])[C@]([H])(CC[C@@]4(C)[C@@]3([H])C[C@]5([H])O[C@]6(CC[C@H](C)CN6)[C@@H](C)[C@]45[H])[C@@]1(C)CC[C@H](O)C2
InChI
1S/C27H45NO2.ClH/c1-16-7-12-27(28-15-16)17(2)24-23(30-27)14-22-20-6-5-18-13-19(29)8-10-25(18,3)21(20)9-11-26(22,24)4;/h16-24,28-29H,5-15H2,1-4H3;1H/t16-,17-,18-,19-,20+,21-,22-,23-,24-,25-,26-,27+;/m0./s1
InChI key
SXXHVPYRDFJKPG-XRWUXUKGSA-N
유사한 제품을 찾으십니까? 방문 제품 비교 안내
일반 설명
Tomatidine is a glycoalkaloid and an aglycone metabolite of tomatine present in high levels in unripe tomato.
애플리케이션
Tomatidine hydrochloride has been used:
- to evaluate its effect on nasopharyngeal carcinoma using cell proliferation and flow cytometry assay
- as a negative control in the non-specific inhibition on hedgehog signaling in hepatocellular carcinoma cell lines
- as a control for cell growth assay and expression studies in pancreatic cancer cells
생화학적/생리학적 작용
Potent inhibitor of Staphylococcus aureus small-colony variants typically seen as complications of cystic fibrosis, with little or no effect on normal S. aureus strains. Also shows antiinflammatory activity by indirectly inhibiting iNOS and COX-2 pathways.
Tomatidine induces the anti-oxidant nuclear factor E2-related factor 2 (Nrf2) and mitophagy, favoring the delay in aging process in C.elegans. It is an inhibitor of muscle atrophy and promotes anabolism in muscle by activating mammalian target of rapamycin complex 1 (mTORC1). It may be useful for treating skeletal muscle atrophy.
신호어
Warning
유해 및 위험 성명서
예방조치 성명서
Hazard Classifications
Acute Tox. 4 Oral
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
개인 보호 장비
Eyeshields, Gloves, type N95 (US)
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
이미 열람한 고객
Tomatidine enhances lifespan and healthspan in C. elegans through mitophagy induction via the SKN-1/Nrf2 pathway
Fang EF, et al.
Scientific reports, 7, 46208-46208 (2017)
Systems-based discovery of tomatidine as a natural small molecule inhibitor of skeletal muscle atrophy
Dyle MC, et al.
Test, 289(21), 14913-14924 (2014)
Expression and regulation of hedgehog signaling pathway in pancreatic cancer
Yang Y, et al.
Langenbeck'S Archives of Surgery / Deutsche Gesellschaft Fur Chirurgie, 395(5), 515-525 (2010)
Aberrant activation of Hedgehog pathway in nasopharyngeal carcinoma
Yue Y, et al.
Clinical and Experimental Medicine, 13(4), 315-322 (2013)
Activation of the hedgehog pathway in human hepatocellular carcinomas
Huang S, et al.
Carcinogenesis, 27(7), 1334-1340 (2006)
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