T2455

T3MG

• 동의어(들): (±)-threo-3-Methylglutamic acid, 3MG, threo-3-Methylglutamate
• 실험식(Hill 표기법): C₆H₁₁NO₄
• CAS Number: 63088-04-0
• Molecular Weight: 161.16
• MDL number: MFCD09836097
• UNSPSC 코드: 12352200
• PubChem Substance ID: 329826708
• NACRES: NA.77

속성

• 형태: powder
• Quality Level: 100
• 색상: white to off-white
• solubility: H₂O: >1.5 mg/dL
• 적합성: suitable for TLC (single spot)
• 저장 온도: room temp
• SMILES string: C[C@@H](CC(O)=O)[C@@H](N)C(O)=O
• InChI: 1S/C6H11NO4/c1-3(2-4(8)9)5(7)6(10)11/h3,5H,2,7H2,1H3,(H,8,9)(H,10,11)/t3-,5+/m0/s1
• InChI key: FHJNAFIJPFGZRI-WVZVXSGGSA-N

설명

생화학적/생리학적 작용

T3MG is a selective inhibitor of excitatory amino acid transporters GLT-1, EAAT2, and EAAT4. T3MG has long been utilized as a gold standard in the study of general EAAT function. It has more recently been shown to be selective for EAAT2 and EAAT4 as compared to EAAT1 and EAAT3 in electrophysiology and glutamate/aspartate uptake assays. Although there are other EAAT2-selective compounds, this is the first tool with selectivity for EAAT4. T3MG is not a substrate for the transporters themselves, nor does it have activity at glutamate ion channels.

특징 및 장점

This compound is featured on the Excitatory Amino Acid Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

제조 메모

T3MG dissolves in water at a concentration that is greater than 1.5 mg/ml.

안전성 정보

• 픽토그램: GHS07
• 신호어: Warning
• 유해 및 위험 성명서: H315 - H319 - H335
• 예방조치 성명서: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• 표적 기관: Respiratory system
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable