SRP8056

Tim-3 (mouse): FC (human)

recombinant, expressed in CHO cells, ≥98% (SDS-PAGE)

• 동의어(들): HAVcr-2, T-cell immunoglobulin and mucin domain-containing protein 3, TIM3, TIMD3
• UNSPSC 코드: 12352200
• NACRES: NA.32

속성

• 생물학적 소스: mouse
• 재조합: expressed in CHO cells
• 분석: ≥98% (SDS-PAGE)
• 양식: lyophilized
• 분자량: monomer 45 kDa by calculation
• 포장: pkg of 100 μg
• 저장 조건: avoid repeated freeze/thaw cycles
• 불순물: <0.06 EU/μg endotoxin, tested
• 색상: white
• UniProt 수납 번호: Q8VIM0
• 배송 상태: wet ice
• 저장 온도: −20°C
• 유전자 정보: mouse ... Havcr2(171285)

설명

일반 설명

Tim-3 is a type I transmembrane protein. It contains an immunoglobulin and a mucin-like domain in its extracellular portion and a tyrosine phosphorylation motif in its cytoplasmic portion. TIM-3 is preferentially expressed on Type 1 T-helper (Th1) and Type 1 CD8⁺ T (Tc1) cells. TIM-3 is also expressed on some dendritic cells. The gene encoding this protein is localized on mouse chromosome 11B1.1.

생화학적/생리학적 작용

The T cell/transmembrane, immunoglobulin and mucin (TIM) family plays a crucial role in regulating immune responses, such as allergy, asthma, transplant tolerance, autoimmunity and also has a control over the response to viral infections. The unique structure of TIM immunoglobulin variable region domains allows highly specific recognition of phosphatidylserine (PtdSer), exposed on the surface of apoptotic cells. Tim-3 generates an inhibitory signal resulting in apoptosis of Type 1 T-helper (Th1) and Type 1 CD8⁺ T (Tc1) cells. It can also mediate phagocytosis of apoptotic cells and cross-presentation of antigen. It functions to inhibit aggressive Th1-mediated auto- and allo-immune responses. Tim-3 pathway blockade by administration of Tim-3: Fc fusion protein accelerates diabetes in non-obese diabetic mice, causes hyperproliferation of Th1 cells and Th1 cytokine release in an experimental autoimmune encephalomyelitis (EAE) model and prevents acquisition of transplantation tolerance induced by costimulation blockade.

물리적 형태

Lyophilized from 0.2 μm-filtered solution in PBS.

재구성

Reconstitute at 100 μg/mL in sterile PBS.

기타 정보

The extracellular domain of mouse Tim-3 (aa 21-189) is fused to the N-terminus of the Fc region of human IgG1.

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 2
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable