SAB4502329

Anti-AMPK α antibody produced in rabbit

affinity isolated antibody

• 동의어(들): 5′-AMP-activated protein kinase, AAPK1, AMPK α-1 chain, AMPK-α1, catalytic α-1 chain
• MDL number: MFCD07370254
• UNSPSC 코드: 12352203
• NACRES: NA.41

속성

• 생물학적 소스: rabbit
• 결합: unconjugated
• 항체 형태: affinity isolated antibody
• 항체 생산 유형: primary antibodies
• 클론: polyclonal
• 형태: buffered aqueous solution
• 분자량: antigen 62 kDa
• 종 반응성: rat, mouse, human
• 농도: ~1 mg/mL
• 기술: ELISA: 1:40000; immunohistochemistry: 1:50-1:100; western blot: 1:500-1:1000
• NCBI 수납 번호: Q13131
• 배송 상태: wet ice
• 저장 온도: −20°C
• 타겟 번역 후 변형: unmodified
• 유전자 정보: human ... AAPK1(5562)

설명

일반 설명

Anti-AMPK α antibody detects endogenous levels of total AMPK α protein.

The AMPK α (protein kinase AMP-activated catalytic subunit α1) gene is located on human chromosome 5p13.1. The gene is evolutionarily conserved.

면역원

The antiserum was produced against synthesized peptide derived from human AMPK alpha.

Immunogen Range: 140-189

애플리케이션

Anti-AMPK α antibody produced in rabbit has been used in immunohistochemistry.

생화학적/생리학적 작용

The AMPK α (protein kinase AMP-activated catalytic subunit α1) gene is associated with the regulation of cell cycle, cell proliferation, energy metabolism and inhibition of rapamycin-pathway. Therefore, it plays an important role in carcinogenesis. From recent studies, variation in the gene is known to be involved in gastric cancer. AMPK α might induce anti-inflammatory response in adipose tissue, upon its activation resulting in a beneficial effect in obesity. Decreased cellular ATP or AMP is known to stimulate AMPK enzyme. Activated AMPK stimulates pathways such as mitochondrial biogenesis, glucose transport in muscle and mitochondrial biogenesis, in order to replenish cellular ATP. On the other hand, it prevents anabolic pathways that consume ATP including biosynthesis of fatty acid and cholesterol as well as adipogenesis. The AMPK signaling pathway is generally stimulated in response to stress, energy deficiency and/or oxygen inadequacy.

특징 및 장점

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

물리적 형태

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• WGK: nwg
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable