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Merck
모든 사진(1)

Key Documents

SRP8051

Sigma-Aldrich

CD152 (human): FC (human) (non-lytic)

recombinant, expressed in CHO cells, ≥98% (SDS-PAGE)

동의어(들):

CTLA-4, Cytotoxic T-lymphocyte-associated antigen 4, Hepatitis A virus cellular receptor 2

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About This Item

UNSPSC 코드:
12352200
NACRES:
NA.32

생물학적 소스

human

재조합

expressed in CHO cells

분석

≥98% (SDS-PAGE)

형태

lyophilized

분자량

monomer 39 kDa by calculation

포장

pkg of 100 μg

불순물

<0.06 EU/μg endotoxin, tested

색상

white

UniProt 수납 번호

배송 상태

wet ice

저장 온도

−20°C

유전자 정보

human ... CTLA4(1493)

일반 설명

CD152 (CTLA-4 (cytotoxic T-lymphocyte associated protein 4)) and CD28 are structurally homologous molecules that are members of the immunoglobulin (Ig) gene superfamily. Both CD152 and CD28 are composed of a single Ig V-like extracellular domain, a transmembrane domain and an intracellular domain.
CD152 and CD28 are both expressed on the cell surface as homodimers or as monomers. CD152 was originally identified as a gene that was specifically expressed by cytotoxic T lymphocytes. However, CD152 transcripts have since been found in both Th1 and Th2, and CD4+ and CD8+ T cell clones. Whereas, CD28 expression is constitutive on the surfaces of 95% of CD4+ T cells and 50% of CD8+ T cells and is down regulated upon T cell activation, CD152 expression is upregulated rapidly following T cell activation and peaks approximately 24 hours following activation. Although both CD152 and CD28 can bind to the same ligands, CD152 binds to B71 and B72 with 20-100-fold higher affinity than CD28.

생화학적/생리학적 작용

CD152 (CTLA-4) and CD28, together with their ligands B7-1 and B7-2 (cluster of differentiation 80 and 86 respectively), constitute one of the dominant costimulatory pathways that regulate T and B cell responses. CTLA-4 (cytotoxic T-lymphocyte associated protein 4) is known to prevent immune responses, and its deficiency causes fatal lymphoproliferation in mouse models. Overexpression of the gene is observed in rheumatoid arthritis. Mutation in CTLA-4 is associated with insulin-dependent (type 1) diabetes mellitus, Grave′s disease and Hashimoto′s thyroiditis.

물리적 형태

Lyophilized from 0.2 μm-filtered solution in PBS.

재구성

Reconstitute at 100 μg/mL in sterile PBS.

기타 정보

The extracellular domain of human CD152 [CTLA-4] (aa 37-160) is fused to the N-terminus of the Fc region of a mutant human IgG1.

Storage Class Code

10 - Combustible liquids

WGK

WGK 2

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable


시험 성적서(COA)

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문서 라이브러리 방문

CTLA-4 and autoimmunity: new insights into the dual regulator of tolerance.
Romo-Tena J, et al.
Autoimmunity Reviews, 12(12), 1171-1176 (2013)
Enhanced expression of CTLA-4 (CD152) on CD4+ T cells in HIV infection.
Steiner K, et al.
Clinical and Experimental Immunology, 115(3), 451-451 (1999)
T-cell regulation by CD28 and CTLA-4.
Alegre M L, et al.
Nature Reviews: Immunology, 1(3), 220-220 (2001)

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