추천 제품
생물학적 소스
mouse
재조합
expressed in CHO cells
태그
FLAG® tagged
분석
>95% (SDS-PAGE)
양식
lyophilized
분자량
35-40 kDa
포장
pkg of 10 μg
저장 조건
avoid repeated freeze/thaw cycles
불순물
<0.01 EU/μg endotoxin, tested
UniProt 수납 번호
배송 상태
wet ice
저장 온도
−20°C
유전자 정보
mouse ... Cd40lg(21947)
일반 설명
CD40L (cluster of differentiation 40 ligand), a member of TNF (tumor necrosis factor) superfamily, is a membrane bound protein. This protein is predominantly expressed transiently by activated CD4+ T cells either as a cell-surface molecule or a secreted multimer protein. Activated B cells, certain DC (dendritic cell) subsets, platelets, and smooth muscle cells also express this protein.
생화학적/생리학적 작용
CD40L (cluster of differentiation 40 ligand) interacts with its receptor CD40 which in turn helps mediate the interaction between APCs (antigen presenting cells) and lymphocytes. Activated platelets produce CD40L which then participates in multiple processes such as endothelial cell reactions, formation of germinal center, T-helper cell priming, and cytotoxic T-cell activation. Platelets are also involved in the pathogenesis of asthma through CD40L where they inhibit the production of regulatory T-cells and promote polarization of T-helper cells. Studies in mice show that this protein confers protection against influenza virus, though in a CD4+ T cell independent manner.
물리적 형태
Lyophilized from PBS.
재구성
Reconstitute with 100 μL deionized water.
기타 정보
Mouse CD40L (aa 115-260) is fused at the N-terminus to mouse ACRP30headless (aa 18-111) and a FLAG®-tag.
법적 정보
FLAG is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class Code
10 - Combustible liquids
WGK
WGK 2
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
가장 최신 버전 중 하나를 선택하세요:
Anwar M Hashem et al.
Journal of immunology (Baltimore, Md. : 1950), 193(2), 722-734 (2014-06-15)
CD40L, a key regulator of the immune system, was studied as both a targeting ligand and a molecular adjuvant in nucleoprotein (NP)-based host defense against influenza in mouse models with different genetic backgrounds. Adenoviral vectors secreting NP-CD40L fusion protein (denoted
Jun Tian et al.
Cellular & molecular immunology, 12(6), 700-707 (2014-11-25)
Platelet activation is associated with multiple immune responses and the pathogenesis of various immune-related diseases. However, the exact role and the underlying mechanism of platelets in the progression of allergic asthma remain largely unclear. In this study, we demonstrate that
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