SRP6576

CREB Binding Protein (1081-1197) GST tag human

recombinant, expressed in E. coli, ≥95% (SDS-PAGE)

• 동의어(들): CBP, CREBBP, cAMP-responsive element-binding protein 1 CREB-1
• UNSPSC 코드: 12352200
• NACRES: NA.32

속성

• 생물학적 소스: human
• 재조합: expressed in E. coli
• 분석: ≥95% (SDS-PAGE)
• 형태: liquid
• 분자량: 40.8 kDa (1081-1197 aa + NT GST Tag)
• 포장: pkg of 20 and 100 μg
• UniProt 수납 번호: Q92793
• 배송 상태: dry ice
• 저장 온도: −70°C
• 유전자 정보: human ... CREB1(1385)

설명

일반 설명

The acetylation of histone lysine residues plays a crucial role in the epigenetic regulation of gene transcription. A bromodomain is a protein domain that recognizes acetylated lysine residues such as those on the N-terminal tails of histones. This recognition is often a prerequisite for protein-histone association and chromatin remodeling. These domains function in the linking of protein complexes to acetylated nucleosomes, thereby controlling chromatin structure and gene expression. Thus, bromodomains serve as “readers” of histone acetylation marks regulating the transcription of target promoters. The cAMP response element-binding protein (CREB) binding protein (CREBBP) bromodomain has been shown to modulate the stability and function of the tumor suppressor protein p53. CREBBP bromodomain recognizes the acetylated lysine residue 382 on p53. This product contains the bromodomain region of CREBBP.

물리적 형태

50 mM Tris, pH 7.5, containing 500 mM sodium chloride, 5 mM β-mercaptoethanol and 5% glycerol.

안전성 정보

• 픽토그램: GHS07
• 신호어: Warning
• 유해 및 위험 성명서: H317 - H319 - H412
• 예방조치 성명서: P273 - P280 - P305 + P351 + P338 - P333 + P313 - P337 + P313
• Hazard Classifications: Aquatic Chronic 3 - Eye Irrit. 2 - Skin Sens. 1
• Storage Class Code: 13 - Non Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable