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Merck
모든 사진(1)

주요 문서

SRP6323

Sigma-Aldrich

Pentraxin 3 human

recombinant, expressed in E. coli, ≥90% (SDS-PAGE)

동의어(들):

PTX3, TNFAIP5, TSG-14

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About This Item

UNSPSC 코드:
12352200
NACRES:
NA.32

생물학적 소스

human

재조합

expressed in E. coli

분석

≥90% (SDS-PAGE)

양식

liquid

분자량

44.4 kDa (401 aa, 18-381 aa + His Tag)

포장

pkg of 100 μg

농도

1 mg/mL

불순물

<1 EU/μg endotoxin (LAL test)

UniProt 수납 번호

배송 상태

dry ice

저장 온도

−70°C

유전자 정보

human ... PTX3(5806)

일반 설명

Pentraxin 3 (PTX3) or tumor necrosis factor (TNF)-stimulated gene is the prototypic member of the long pentraxin family sharing the C-terminal domain with short pentraxins and containing a unique N-terminal domain. The gene encoding this protein is localized on human chromosome 3q25.32 and consists of 3 exons. Recombinant human Pentraxin 3 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography.

생화학적/생리학적 작용

Pentraxin 3 (PTX3) is an acute phase protein produced and released at inflammatory sites by diverse cell types including monocytes/macrophages, endothelial cells, vascular smooth muscle cells, fibroblasts, and adipocytes. It plays a role in the regulation of innate resistance to pathogens, inflammatory reactions, possibly clearance of self-components and female fertility. PTX3 particularly functions as a soluble pathogen recognition receptor and confers resistance against pathogens. Studies indicate that the protein removes apoptotic cells during immune responses. It associates with complement factor H, which is a complement regulator protein.

물리적 형태

1 mg/mL in 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol, and 1 mM DTT.

픽토그램

Exclamation mark

신호어

Warning

유해 및 위험 성명서

Hazard Classifications

Eye Irrit. 2

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable


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시험 성적서(COA)

Lot/Batch Number

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문서 라이브러리 방문

Bongkun Choi et al.
Oncotarget, 5(2), 481-492 (2014-01-25)
Pentraxin 3 (PTX3), a modulator of tumor-associated inflammation, is known to be positively correlated with tumor grade and severity of malignancies, but its exact role remains unclear. This study found that PTX3 expression was up-regulated in distant bone metastases of
Pentraxin 3 Activates JNK Signaling and Regulates the Epithelial-To-Mesenchymal Transition in Renal Fibrosis.
Hung TW
Cellular Physiology and Biochemistry, 40(5), 1029-1038 (2016)
Simone Bastrup-Birk et al.
PloS one, 8(9), e73119-e73119 (2013-09-17)
The long pentraxin-3 (PTX3) is a key component of the humoral arm of the innate immune system. PTX3 is produced locally in response to pro-inflammatory stimuli. To investigate PTX3 levels and its use as a biomarker in patients with systemic
Pentraxin-3 and the right ventricle: the Multi-Ethnic Study of Atherosclerosis?Right Ventricle Study
Peter Leary
Pulmonary Circulation, 4.2 (2014)
Tunicamycin-induced Endoplasmic Reticulum Stress Upregulates the Expression of Pentraxin 3 in Human Retinal Pigment Epithelial Cells
Narae Hwang
Korean Journal of Ophthalmology : KJO, 30(6), 468-478 (2016)

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