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Merck
모든 사진(1)

주요 문서

SRP5154

Sigma-Aldrich

14-3-3 ε, untagged human

recombinant, expressed in E. coli, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

동의어(들):

14-3-3 ε, 14-3-3E, FLJ45465, KCIP-1, MDCR, MDS, YWHAE

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About This Item

CAS Number:
UNSPSC 코드:
12352202
NACRES:
NA.32

생물학적 소스

human

재조합

expressed in E. coli

분석

≥70% (SDS-PAGE)

형태

buffered aqueous glycerol solution

분자량

~30 kDa

NCBI 수납 번호

응용 분야

cell analysis

배송 상태

dry ice

저장 온도

−70°C

유전자 정보

human ... YWHAE(7531)

일반 설명

14-3-3ε also known as tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein is a member of the 14-3-3 family. 14-3-3ε has been reported to be involved in heat shock transcription factor 1 (HSF1) and extracellular signal regulated protein kinase (ERK) pathways. 14-3-3ε interaction with the deubiquitinating enzyme UBPY, also known as USP8, regulates cargo sorting and membrane traffic at early endosomes. Association of 14-3-3ε, HSF1 with ERK during heat shock may modulate the amplitude of the response and control the termination of HSP expression on resumption of growth conditions.

물리적 형태

Supplied in 50mM Tris-HCl, pH 7.5, 50mM NaCl, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.

제조 메모

after opening, aliquot into smaller quantities and store at -70 °C. Avoid repeating handling and multiple freeze/thaw cycles

Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable


시험 성적서(COA)

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문서 라이브러리 방문

Emi Mizuno et al.
Experimental cell research, 313(16), 3624-3634 (2007-08-28)
The deubiquitinating enzyme UBPY, also known as USP8, regulates cargo sorting and membrane traffic at early endosomes. Here we demonstrate the regulatory mechanism of the UBPY catalytic activity. We identified 14-3-3 epsilon, gamma, and zeta as UBPY-binding proteins using co-immunoprecipitation
Xiaozhe Wang et al.
The Journal of biological chemistry, 279(47), 49460-49469 (2004-09-15)
Cytoprotection during the heat shock response is a complex phenomenon involving multiple inducible mechanisms. We have examined the interaction of two key molecular components in the response, heat shock transcription factor 1 (HSF1) and extracellular signal regulated protein kinase (ERK).

자사의 과학자팀은 생명 과학, 재료 과학, 화학 합성, 크로마토그래피, 분석 및 기타 많은 영역을 포함한 모든 과학 분야에 경험이 있습니다..

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