추천 제품
생물학적 소스
human
재조합
expressed in baculovirus infected Sf9 cells
분석
≥70% (SDS-PAGE)
형태
buffered aqueous glycerol solution
분자량
~110 kDa
NCBI 수납 번호
응용 분야
cell analysis
배송 상태
dry ice
저장 온도
−70°C
유전자 정보
human ... TP73(7161)
일반 설명
p73α is a member of the p53 family of transcription factors that are involved in cellular responses to stress and development. P73 has high sequence similarity to p53 and p63, which allows p63 and p73 to transactivate p53-responsive genes causing cell cycle arrest and apoptosis. P73 is a stress-response gene and a downstream effector in the p53 pathway. The p73 protein is expressed at very low levels in normal tissues and is differentially expressed in a number of tumors. p73 is the components of a mismatch repair-dependent apoptosis pathway which contributes to cisplatin-induced cytotoxicity.
물리적 형태
Supplied in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
제조 메모
after opening, aliquot into smaller quantities and store at -70 °C. Avoid repeating handling and multiple freeze/thaw cycles
Storage Class Code
10 - Combustible liquids
WGK
WGK 1
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
Jianli Wang et al.
The Journal of biological chemistry, 282(40), 29152-29162 (2007-08-19)
TAp73 is a p53 tumor suppressor gene homologue that is known to be mainly involved in apoptosis. We report here that TAp73 is necessary for the cellular response to oxidative stress and that TAp73 functions as a downstream target of
J G Gong et al.
Nature, 399(6738), 806-809 (1999-07-03)
Cancer chemotherapeutic agents such as cisplatin exert their cytotoxic effect by inducing DNA damage and activating programmed cell death (apoptosis). The tumour-suppressor protein p53 is an important activator of apoptosis. Although p53-deficient cancer cells are less responsive to chemotherapy, their
자사의 과학자팀은 생명 과학, 재료 과학, 화학 합성, 크로마토그래피, 분석 및 기타 많은 영역을 포함한 모든 과학 분야에 경험이 있습니다..
고객지원팀으로 연락바랍니다.