추천 제품
재조합
expressed in E. coli
분석
≥70% (SDS-PAGE)
양식
buffered aqueous glycerol solution
특이 활성도
8,415-11,385 nmol/min·mg
분자량
~116 kDa
NCBI 수납 번호
배송 상태
dry ice
저장 온도
−70°C
유전자 정보
mouse ... Ptprc(19264)
일반 설명
Protein tyrosine phosphatase, receptor type, C (PTPRC) or CD45 contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus belongs to receptor type PTP. This gene is specifically expressed in hematopoietic cells.
생화학적/생리학적 작용
Protein tyrosine phosphatase, receptor type, C (PTPRC) has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling.
물리적 형태
Supplied in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
제조 메모
after opening, aliquot into smaller quantities and store at -70 °C. Avoid repeating handling and multiple freeze/thaw cycles
Storage Class Code
10 - Combustible liquids
WGK
WGK 1
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
가장 최신 버전 중 하나를 선택하세요:
Mutation in the CD45 Inhibitory Wedge Modulates Integrin Activation and Leukocyte Recruitment during Inflammation
Giulia Germena
Journal of Immunology (2015)
High CD45 surface expression determines relapse risk in children with precursor B-cell and T-cell acute lymphoblastic leukemia treated according to the ALL-BFM 2000 protocol
Gunnar Cario
Haematologica (2014)
E H Fischer et al.
Science (New York, N.Y.), 253(5018), 401-406 (1991-07-26)
Protein tyrosine phosphatases (PTPs) represent a diverse family of enzymes that exist as integral membrane and nonreceptor forms. The PTPs, with specific activities in vitro 10 to 1000 times greater than those of the protein tyrosine kinases would be expected
S J Ralph et al.
The EMBO journal, 6(5), 1251-1257 (1987-05-01)
Structural variation in the primary structure of human T200 glycoprotein has been detected. Three cDNA variants have been characterized each of which encode T200 molecules that differ in size as a result of sequence differences in their amino-terminal regions. The
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