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Merck
모든 사진(2)

주요 문서

SRP0444

Sigma-Aldrich

A20 human

recombinant, expressed in baculovirus infected Sf9 cells, ≥20% (SDS-PAGE)

동의어(들):

OTU domain-containing protein 7C, OTUD7C, TNFAIP3, tumor necrosis factor-? induced protein 3

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About This Item

UNSPSC 코드:
12352202
NACRES:
NA.32

생물학적 소스

human

재조합

expressed in baculovirus infected Sf9 cells

분석

≥20% (SDS-PAGE)

양식

aqueous solution

분자량

90.5 kDa

포장

pkg of 50 μg

NCBI 수납 번호

UniProt 수납 번호

배송 상태

dry ice

저장 온도

−70°C

유전자 정보

human ... TNFAIP3(7128)

일반 설명

Human A20, also known as tumor necrosis factor-α induced protein 3 (TNFAIP3) or OTU domain-containing protein 7C (OTUD7C), (GenBank Accession No. NM_006290) amino acids 2-791(end) with an N-terminal FLAG-tag, MW=90.5 kDa, expressed in Sf9 insect cells via a Baculovirus expression system.

애플리케이션

Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.

Storage Class Code

10 - Combustible liquids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable


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문서 라이브러리 방문

Jing Liu et al.
Journal of biomedical science, 20, 74-74 (2013-10-09)
Intestinal polyps may further develop into colon cancer; the pathogenesis is not clear. The p53 gene is an important anti-cancer gene in the body, which is suppressed in cancer. The ubiquitin E3 ligase A20 (A20) plays a role in regulating
Chong-Shan Shi et al.
Autophagy, 6(7), 986-987 (2010-08-28)
Toll-like receptor 4 (TLR4) signaling triggers autophagy, which has been linked to both adaptive and innate immunity. Engagement of TLR4 recruits to the receptor complex Beclin 1, a key component of a class III phosphatidylinositol 3-kinase complex (PI3KC3) that initiates
Sarah G Hymowitz et al.
Nature reviews. Cancer, 10(5), 332-341 (2010-04-13)
Clinicians have suspected for hundreds of years that chronic activation of the immune system contributes to the development of cancer. However, the molecular mechanisms that mediate this precarious interplay are only now being elucidated. Recent reports have identified A20 as
Rita M Tavares et al.
Immunity, 33(2), 181-191 (2010-08-14)
A20 is a ubiquitin modifying enzyme that restricts NF-kappaB signals and protects cells against tumor necrosis factor (TNF)-induced programmed cell death. Given recent data linking A20 (TNFAIP3) with human B cell lymphomas and systemic lupus erythematosus (SLE), we have generated

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