SML3711

DENSPM tetrahydrochloride

≥98% (HPLC)

• 동의어(들): BE 333 HCl, BENSpm HCl, DENSpm 4HCl, N1,N11-Diethylnorspermine tetrahydrochloride, N1,N11-bis(ethyl)norspermine tetrahydrochloride
• 실험식(Hill 표기법): C₁₃H₃₂N₄· 4HCl
• CAS Number: 156886-85-0
• Molecular Weight: 390.26
• MDL number: MFCD00871200
• UNSPSC 코드: 41121800
• UNSPSC 코드: 12352200
• NACRES: NA.21

속성

• Quality Level: 100
• 분석: ≥98% (HPLC)
• 양식: powder
• 저장 조건: desiccated
• 색상: white to beige
• solubility: H₂O: 2 mg/mL, clear
• 저장 온도: -10 to -25°C

설명

생화학적/생리학적 작용

DENSPM HCl is a nontoxic polyamine analog that enhances polyamine catabolism and production of hazardous hydrogen peroxide and N-acetyl-3-aminopropanal by inducing spermidine/spermine-N1-acetyl transferase (SSAT) expression. DENSPM HCl improves stem cell maintenance through reduced translation, exhibits slower proliferation rates in cancer cells, and induces autophagy. It shows greater antitumor activity and less associated toxicity in a human melanoma xenograft model.

Polyamine pathway inhibitor; potent inducer of spermidine/spermine N1-acetyltransferase

주의사항

Hygroscopic

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable