SML3620

UNC2250

≥98% (HPLC)

• 동의어(들): UNC 2250, UNC-2250, trans-4-((2-(Butylamino)-5-(5-(morpholinomethyl)pyridin-2-yl)pyrimidin-4-yl)amino)cyclohexanol
• 실험식(Hill 표기법): C₂₄H₃₆N₆O₂
• CAS Number: 1493694-70-4
• Molecular Weight: 440.58
• MDL number: MFCD27992060
• UNSPSC 코드: 12352200
• NACRES: NA.25

속성

• Quality Level: 100
• 분석: ≥98% (HPLC)
• 양식: powder
• 색상: white to beige
• solubility: DMSO: 2 mg/mL, clear (Warmed)
• 저장 온도: -10 to -25°C
• SMILES string: N4(CCOCC4)Cc1cnc(cc1)c2c(nc(nc2)NCCCC)N[C@@H]3CC[C@H](CC3)O
• InChI key: HSYSSKFCQHXOBP-MXVIHJGJSA-N

설명

생화학적/생리학적 작용

Potent and highly selective Mer receptor tyrosine kinase (MerTK) inhibitor in vitro and in vivo.

UNC2250 is a potent and highly selective Mer receptor tyrosine kinase inhibitor (MerTK IC50 = 1.7 nM; Tyro3/Axl IC50 = 100/270 nM) that reduces endogenous Mer phosphorylation level (697 B-ALL IC50 = 9.8 nM post 1h treatment) and blocks ligand-stimulated activation of a chimeric EGFR-Mer in cells. UNC2250 inhibits colony-forming potential in rhabdoid (by 36% at 100 nM; BT-12 cells) and NSCLC tumor cells (Colo699 IC50 = 100 nM) with good pharmacokinetic properties. UNC2250 is reported to reduce mortality in a murine LPS-induced acute lung injury (ALI) model (2 mg/kg i.v. )

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable