SML3488

CuATSP

≥98% (HPLC)

• 동의어(들): (SP-4-2)-[[2,2′-(1,2-Dimethyl-1,2-ethanediylidene)bis[N-phenylhydrazinecarbothioamidato-κN2,κS]](2-)]copper, Cu ATSP, Cu-ATSP
• 실험식(Hill 표기법): C₁₈H₁₈CuN₆S₂
• CAS Number: 68341-12-8
• Molecular Weight: 446.05
• UNSPSC 코드: 12352200
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥98% (HPLC)
• 형태: powder
• 색상: , Faint brown to dark red
• solubility: DMSO: 2 mg/mL, clear (Warmed)
• 저장 온도: 2-8°C
• SMILES string: CC1=[N]2[Cu]3(SC(NC4=CC=CC=C4)=N2)SC(NC5=CC=CC=C5)=N[N]3=C1C

설명

생화학적/생리학적 작용

CuATSP is a CuATSM analog with >10-fold enhanced ferropotosis inhibitory potency (CuATSP/CuATSM IC50 against 150 nM RSL3-induced ferroptosis = 8.5/160 nM using Pfa1 mouse embryonic fibroblasts,16/170 nM using HT-22 mouse hippocampal cells). CuATSP and CuATSM exert their radical-trapping antioxidant (RTA) and (phospho)lipid peroxidation inhibitory potency via an initial reversible addition of a peroxyl radical to the bis(thiosemicarbazone) ligand, followed by a subsequent H-atom transfer (HAT) that drives the reaction forward.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable