SML3456

LUF7244

≥98% (HPLC)

• 동의어(들): 2-​[4-​(3-​Chlorobenzoyl)​phenoxy]​-​N-​3-​pyridinyl-acetamide
• 실험식(Hill 표기법): C₂₀H₁₅ClN₂O₃
• CAS Number: 1821638-43-0
• Molecular Weight: 366.80
• UNSPSC 코드: 12352200
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥98% (HPLC)
• 양식: powder
• 색상: white to beige
• solubility: DMSO: 2 mg/mL, clear
• 저장 온도: −20°C
• SMILES string: O=C(NC1=CC=CN=C1)COC2=CC=C(C=C2)C(C3=CC=CC(Cl)=C3)=O

설명

생화학적/생리학적 작용

LUF7244 is a potent and selective voltage-gated potassium 11.1 (Kv11.1) channels negative allosteric modulator/activator that inhibits early afterdepolarizations in vitro. It decreases the affinity of Kv11.1 for cisapride, astemizole, dofetilide and sertindole. LUF7244 averts dofetilide‐induced torsades de pointes arrhythmias in dogs with chronic atrioventricular block. LUF7244 in combination with dofetilide rescues both congenital and acquired Kv11.1 trafficking defects and produces functional Kv11.1 current in trafficking defective G601S-Kv11.1 cells.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable