SML3425

Harpagoside

≥98% (HPLC)

• 동의어(들): (1S ,4aS ,5R ,7S ,7aS )-1,4a,5,6,7,7a-Hexahydro-4a,5-dihydroxy-7-methyl-7-[[(2E )-1-oxo-3-phenyl-2-propen-1-yl]oxy]cyclopenta[c ]pyran-1-yl β-D-glucopyranoside
• 실험식(Hill 표기법): C₂₄H₃₀O₁₁
• CAS Number: 19210-12-9
• Molecular Weight: 494.49
• UNSPSC 코드: 12352200
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥98% (HPLC)
• 형태: powder
• 광학 활성: [α]/D -50 to -30°
• 색상: white to beige
• solubility: DMSO: 2 mg/mL, clear
• 저장 온도: -10 to -25°C
• InChI: 1S/C24H30O11/c1-23(35-16(27)8-7-13-5-3-2-4-6-13)11-15(26)24(31)9-10-32-22(20(23)24)34-21-19(30)18(29)17(28)14(12-25)33-21/h2-10,14-15,17-22,25-26,28-31H,11-12H2,1H3/b8-7+/t14-,15-,17-,18+,19-,20-,21+,22+,23+,24-/m1/s1
• InChI key: KVRQGMOSZKPBNS-FMHLWDFHSA-N

설명

생화학적/생리학적 작용

Harpagoside is an orally available iridoid glycoside and an active component of Harpagophytum extract with cardioprotective effects. Harpagoside is shown to directly bind to and activate ACE2. Allosterically inhibits ACE2 binding to spike protein and reduces viral entry and lessen SARS-CoV-2 infection. Harpagoside was reported to suppress AP-1, IL-6, COX-1/2, c-FOS, NF-ĸB expression and upregulate BMP2 and Wnt signaling pathways.

안전성 정보

• 픽토그램: GHS07
• 신호어: Warning
• 유해 및 위험 성명서: H302
• 예방조치 성명서: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable