SML3397

SRT3025 hydrochloride

≥98% (HPLC)

• 동의어(들): 3025 HCl; 5-(3-Methoxypropyl)-2-phenyl-N-(2-(6-(pyrrolidin-1-ylmethyl)thiazolo[5,4-b]pyridin-2-yl)phenyl)thiazole-4-carboxamide, hydrochloride salt, 5-(3-Methoxypropyl)-2-phenyl-N-[2-[6-(1-pyrrolidinylmethyl)thiazolo[5,4-b]pyridin-2-yl]phenyl]-4-thiazolecarboxamide, hydrochloride salt, SRT 3025 HCl, SRT-3025 HCl, Sirtuin modulator 1
• 실험식(Hill 표기법): C₃₁H₃₁N₅O₂S₂ · xHCl
• Molecular Weight: 569.74 (free base basis)
• UNSPSC 코드: 12352200
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥98% (HPLC)
• 양식: powder
• 저장 조건: desiccated
• 색상: white to beige
• solubility: DMSO: 2 mg/mL, clear (Warmed)
• 저장 온도: -10 to -25°C
• SMILES string: O=C(C1=C(CCCOC)SC(C2=CC=CC=C2)=N1)NC3=C(C4=NC5=CC(CN6CCCC6)=CN=C5S4)C=CC=C3.[xHCl]

설명

생화학적/생리학적 작용

Orally active sirtuin 1 (Sirt1) activator in cultures and in vivo.

SRT3025 is an orally active sirtuin 1 activator (Sirt1 EC1.5 ≤1 μM, Emax ≥150% and <300%) that reduces cellular acetylation of Sirt1 substrates FoxO1 (induced by RANKL ) and histone 3 (1-10 μM; murine bone marrow macrophages) and exhibits in vivo efficacy in a murine atherosclerosis model (3.18 g/kg high-cholesterol diet; mice) and ovariectomy-induced bone loss in female mice (50 & 100 mg/kg via daily p.o.).

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable