SML3287

Sulfopin

≥98% (HPLC)

• 동의어(들): 2-Chloro-N-(2,2-dimethylpropyl)-N-(tetrahydro-1,1-dioxido-3-thienyl)-acetamide
• 실험식(Hill 표기법): C₁₁H₂₀ClNO₃S
• CAS Number: 2451481-08-4
• Molecular Weight: 281.80
• MDL number: MFCD32860123
• UNSPSC 코드: 12352200
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥98% (HPLC)
• 양식: powder
• 색상: white to beige
• solubility: DMSO: 2 mg/mL, clear
• 저장 온도: 2-8°C
• SMILES string: [S]1(=O)(=O)CC(CC1)N(CC(C)(C)C)C(=O)CCl
• InChI: 1S/C11H20ClNO3S/c1-11(2,3)8-13(10(14)6-12)9-4-5-17(15,16)7-9/h9H,4-8H2,1-3H3
• InChI key: NMHVAHHYKGXBMY-UHFFFAOYSA-N

설명

생화학적/생리학적 작용

Sulfopin is an in vivo active, highly potent, and selective covalent inhibitor of the peptidyl-prolyl isomerase NIMA-interacting-1 (Pin1) that binds to active site Cys113. Sulfopin induces downregulation of c-Myc target genes, inhibits tumor progression. It extends survival in murine and zebrafish models of MYCN-driven neuroblastoma, and in a murine model of pancreatic cancer.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable