SML3252
SF3B1 Protein Degrader
≥95% (HPLC)
동의어(들):
2-((4-chlorophenyl)amino)-N-(6-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)hexyl)thiazole-4-carboxamide, O4I2-based PROTAC® degrader
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모든 사진(1)
About This Item
실험식(Hill 표기법):
C29H29ClN6O5S
Molecular Weight:
609.10
UNSPSC 코드:
12352202
NACRES:
NA.77
추천 제품
Quality Level
분석
≥95% (HPLC)
양식
powder
저장 조건
under inert gas
색상
white to beige
solubility
DMSO: 2 mg/mL, clear
저장 온도
2-8°C
SMILES string
O=C1N(C(C2=C1C=CC=C2NCCCCCCNC(C3=CSC(NC4=CC=C(C=C4)Cl)=N3)=O)=O)C5CCC(NC5=O)=O
InChI key
UWYLVQJEOCYCEW-UHFFFAOYSA-N
생화학적/생리학적 작용
Cell permeable degrader of splicing factor 3B1 (SF3B1)
SF3B1 Protein degrader (reported as "PROTAC-O4I2" in Gama-Brambila et al.) is a cell permeable degrader of splicing factor 3B1 (SF3B1) containing an SF3B1 activator O4I2 connected to the ligand of the cereblon ubiquitin ligase thalidomide. PROTAC-O4I2 selectively degrades SF3B1 in cells. It induces apoptosis of tumor cells and extends survival in Drosophila intestinal tumor model.
법적 정보
PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
가장 최신 버전 중 하나를 선택하세요:
Rodrigo A Gama-Brambila et al.
Cell chemical biology, 28(11), 1616-1627 (2021-05-29)
The proteolysis-targeting chimeras (PROTACs) are a new technology to degrade target proteins. However, their clinical application is limited currently by lack of chemical binders to target proteins. For instance, it is still unknown whether splicing factor 3B subunit 1 (SF3B1)
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