SML2806
MALAT1-IN-5
≥95% (HPLC)
동의어(들):
5-(4-Methoxyphenyl)-N-[(3-methoxyphenyl)methyl]-1-methyl-1H-imidazol-2-amine, Malat1 inhibitor compound 5, N-(3-Methoxybenzyl)-5-(4-methoxyphenyl)-1-methyl-1H-imidazol-2-amine, TC SL C5
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모든 사진(1)
About This Item
실험식(Hill 표기법):
C19H21N3O2
CAS Number:
Molecular Weight:
323.39
MDL number:
UNSPSC 코드:
12352200
NACRES:
NA.77
추천 제품
생화학적/생리학적 작용
MALAT1-IN-5 reduces the long noncoding (lnc) RNA metastasis-associated lung adenocarcinoma transcript 1 (Malat1) level (by 54% in 7 days at 1 μM; MMTV-PyMT tumors organoids) via specific interaction with Malat1 triple-helical configuration of 3′-terminal element for nuclear expression (ENE KD = 2.9 μM under physiologic ionic conditions), but not the homologous 3′-end triple-helix of Neat1 (MENβ) lncRNA. MALAT1-IN-5 decreases MMTV-PyMT organoid branching morphogenesis (by 38% in 7 days at 1 μM) and modulates the levels of Malat1-targeted mRNAs Krt16 & Csn2.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
Fardokht A Abulwerdi et al.
ACS chemical biology, 14(2), 223-235 (2019-01-09)
Metastasis-associated lung adenocarcinoma transcript 1 ( Malat1/ MALAT1, mouse/human), a highly conserved long noncoding (lnc) RNA, has been linked with several physiological processes, including the alternative splicing, nuclear organization, and epigenetic modulation of gene expression. MALAT1 has also been implicated
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