추천 제품
분석
≥98% (HPLC)
형태
powder
색상
white to beige
solubility
DMSO: 2 mg/mL, clear
저장 온도
2-8°C
SMILES string
OC(C(NC1=CC(C(F)(F)F)=C(C#N)C=C1)=O)(C)COC2=CC(C(F)(F)F)=CC(C(F)(F)F)=C2
생화학적/생리학적 작용
SK33, a trifluoromethylated enobosarm analog, is a cell and brain penetrant, tissue selective and highly potent anti-androgen that reduces androgen receptor (AR) transcriptional activity. SK33 induces cell cycle arrest at G1 phase. It exhibits increased efficacy against acquired anti-androgen resistance prostate cancer cells.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
Salvatore Ferla et al.
Bioorganic & medicinal chemistry letters, 26(15), 3636-3640 (2016-06-16)
Prostate cancer is a major cause of male death worldwide and the identification of new and improved treatments is constantly required. Among the available options, different non-steroidal androgen receptor (AR) antagonists are approved also to treat castration-resistant forms. Most of
D Alwyn Dart et al.
Molecular cancer therapeutics, 17(9), 1846-1858 (2018-06-14)
Prostate cancer often develops antiandrogen resistance, possibly via androgen receptor (AR) mutations, which change antagonists to agonists. Novel therapies with increased anticancer activity, while overcoming current drug resistance are urgently needed. Enobosarm has anabolic effects on muscle and bone while
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