SML2408

UNC3866 trifluoroacetate salt

≥98% (HPLC)

• 동의어(들): N-[4-(1,1-Dimethylethyl)benzoyl]-L-phenylalanyl-L-alanyl-L-leucyl-N6,N6-diethyl-L-lysyl-L-Serine methyl ester trifluoroacetate
• 실험식(Hill 표기법): C₄₃H₆₆N₆O₈
• Molecular Weight: 795.02
• UNSPSC 코드: 12352200

속성

• 분석: ≥98% (HPLC)
• 형태: lyophilized powder (white)
• 색상: white to off-white
• 배송 상태: wet ice
• 저장 온도: −20°C

설명

생화학적/생리학적 작용

Antagonist of chromodomains CBX4/7 of Polycomb repressive complex 1

UNC3866 inhibits the CBX chromodomains of the Polycomb repressive complex 1 (PRC1), which is involved in transcriptional repression. UNC3866 selectively targets CBX4 and CBX7 most potently, with Kd values of ∼100 nM. The PRC1 chromodomains facilitate PRC1-mediated transcriptional repression by targeting the complex to Trimethyllysine 27 on histone 3 (H3K27me3). UNC3866 antagonizes the methyllysine (Kme) reading function, and has been shown to inhibit the PC3 prostate cancer cell proliferation associated with CBX7 overexpression.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable