SML2309

Oxaphenamide

≥98% (HPLC)

• 동의어(들): 2-Hydroxy-N-(4-hydroxyphenyl)benzamide, 4′-Hydroxysalicylanilide, Osalmide, Oxaphenamide, p-hydroxyphenylsalicylamide
• 실험식(Hill 표기법): C₁₃H₁₁NO₃
• CAS Number: 526-18-1
• Molecular Weight: 229.23
• EC Number: 208-385-9
• MDL number: MFCD00020026
• UNSPSC 코드: 12352200
• NACRES: NA.77

속성

• 분석: ≥98% (HPLC)
• 양식: powder
• 색상: white to beige
• solubility: DMSO: 2 mg/mL, clear
• 저장 온도: 2-8°C
• SMILES string: N(c2ccc(cc2)O)C(=O)c1c(cccc1)O
• InChI: 1S/C13H11NO3/c15-10-7-5-9(6-8-10)14-13(17)11-3-1-2-4-12(11)16/h1-8,15-16H,(H,14,17)
• InChI key: LGCMKPRGGJRYGM-UHFFFAOYSA-N

설명

생화학적/생리학적 작용

Osalmid is a potent inhibitor of ribonucleotide reductase small subunit M2 (RRM2) that potently inhibits HBV DNA and cccDNA synthesis in HepG2.2.15 cells. Osalmid inhibits RR (ribonucleotide reductase) activity in vivo, and exhibits synergistic effect with lamivudine on inactivation mutant HBV strain. Osalmid is a biliation activator (choleretic agent), but a mechanism of this activity remains unknown.

potent inhibitor of ribonucleotide reductase small subunit M2 (RRM2) that potently inhibits HBV DNA and cccDNA synthesis; choleretic agent

안전성 정보

• 픽토그램: GHS07
• 신호어: Warning
• 유해 및 위험 성명서: H302
• 예방조치 성명서: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3