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Merck
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주요 문서

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SML2295

Sigma-Aldrich

Dimethyoxy-etomidate

≥98% (HPLC)

동의어(들):

(R)-ethyl 1-(1-(3,5-dimethoxyphenyl)ethyl)-1H-imidazole-5-carboxylate

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About This Item

실험식(Hill 표기법):
C16H20N2O4
CAS Number:
2300142-82-7
Molecular Weight:
304.34
UNSPSC 코드:
12352200

분석

≥98% (HPLC)

양식

oil

색상

colorless to light brown

저장 온도

2-8°C

SMILES string

C[C@@H](N1C=NC=C1C(OCC)=O)C2=CC(OC)=CC(OC)=C2

InChI

1S/C16H20N2O4/c1-5-22-16(19)15-9-17-10-18(15)11(2)12-6-13(20-3)8-14(7-12)21-4/h6-11H,5H2,1-4H3/t11-/m1/s1

InChI key

JETTTZITBCWAQX-LLVKDONJSA-N

생화학적/생리학적 작용

Dimethyoxy-etomidate is a phenyl ring substituted etomidate analog.
Dimethyoxy-etomidate is a potent suppressor of adrenocortical steroid synthesis by inhibiting steroid 11β-hydroxylase. Dimethyoxy-etomidate is essentially divided of etomidate′s GABAA receptor positive modulatory and sedative-hypnotic activities.
potent suppressor of adrenocortical steroid synthesis, selective inhibitor of steroid 11β-hydroxylase

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

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시험 성적서(COA)

Lot/Batch Number

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문서 라이브러리 방문

Megan McGrath et al.
The Journal of pharmacology and experimental therapeutics, 364(2), 229-237 (2017-12-06)
Cushing's syndrome is characterized by the overproduction of adrenocortical steroids. Steroidogenesis inhibitors are mainstays of medical therapy for Cushing's syndrome; unfortunately, adverse side effects and treatment failures are common with currently available drugs. The general anesthetic induction agent etomidate is
Behavioral and steroidogenic pharmacology of phenyl ring substituted etomidate analogs in rats
McGrath M, et al.
BMC Pharmacology & Toxicology, 20, 1-9 (2019)

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