SML2109

ST034307

≥98% (HPLC)

• 동의어(들): 6-Chloro-2-(trichloromethyl)-4H-1-benzopyran-4-one, 6-Chloro-2-(trichloromethyl)chromen-4-one
• 실험식(Hill 표기법): C₁₀H₄Cl₄O₂
• CAS Number: 133406-29-8
• Molecular Weight: 297.95
• MDL number: MFCD00760793
• UNSPSC 코드: 12352200
• NACRES: NA.77

속성

• 분석: ≥98% (HPLC)
• 양식: powder
• 색상: faint green to dark gray
• solubility: DMSO: 2 mg/mL, clear (warmed)
• 저장 온도: −20°C
• SMILES string: ClC(Cl)(Cl)C1=CC(C2=CC(Cl)=CC=C2O1)=O
• InChI: 1S/C10H4Cl4O2/c11-5-1-2-8-6(3-5)7(15)4-9(16-8)10(12,13)14/h1-4H

설명

생화학적/생리학적 작용

ST034307 is a selective inhibitor of adenylyl cyclase 1 (AC1) with analgesic activity. Adenylyl cyclase 1 has been shown to be a potential target for treating pain and reducing the dependency on opioids, but it has been difficult to inhibit AC1 selectively without also inhibiting other isoforms vital to physiological functions. ST034307 is selective for AC1 over all eight other adenylyl cyclase isoforms. It inhibited AC1 and reduced cAMP, while leaving AC8 unaffected and was shown to reduce pain in a mouse inflammatory pain model.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3