SML1740

FIN56

≥98% (HPLC)

• 동의어(들): N2,N7-Dicyclohexyl-9-(hydroxyimino)-9H-fluorene-2,7-disulfonamide
• 실험식(Hill 표기법): C₂₅H₃₁N₃O₅S₂
• CAS Number: 1083162-61-1
• Molecular Weight: 517.66
• UNSPSC 코드: 12352200
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥98% (HPLC)
• 양식: powder
• 색상: white to beige
• solubility: DMSO: 20 mg/mL, clear
• 저장 온도: room temp
• SMILES string: [S](=O)(=O)(NC5CCCCC5)c1cc2c(cc1)c3c(cc(cc3)[S](=O)(=O)NC4CCCCC4)C2N=O
• InChI: 1S/C25H31N3O5S2/c29-26-25-23-15-19(34(30,31)27-17-7-3-1-4-8-17)11-13-21(23)22-14-12-20(16-24(22)25)35(32,33)28-18-9-5-2-6-10-18/h11-18,25,27-28H,1-10H2
• InChI key: OYLSCKVHQYAZEE-UHFFFAOYSA-N

설명

생화학적/생리학적 작용

FIN56 is a specific inducer of ferroptosis, a non-apoptotic form of cell death characterized by iron-dependent accumulation of lipid peroxidation products and lethal reactive oxygen species (ROS). FIN56 has an EC₅₀ value of 240 nM, and is believed to act though two separate pathways. The first requires the enzymatic activity of acetyl-CoA carboxylase (ACC),and results in degradation of glutathione peroxidase 4 (GPX4), which acts as a negative regulator of ferroptosis by reducing lipid hydroperoxides. The second pathway involves FIN56 binding to and activing squalene synthase, which leads to coenzyme Q10 depletion.

FIN56 is a specific inducer of ferroptosis.

Ferroptosis inducer 56 (FIN56) is a member of the class 3 ferroptosis inducers.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable