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Merck
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주요 문서

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SML2794

Sigma-Aldrich

Erastin2

≥98% (HPLC)

동의어(들):

2-((4-(2-(4-Chlorophenoxy)acetyl)piperazin-1-yl)methyl)-3-(4-isopropoxybiphenyl-3-yl)quinazolin-4(3H)-one, 2-[[4-[2-(4-Chlorophenoxy)acetyl]-1-piperazinyl]methyl]-3-[4-(1-methylethoxy)[1,1′-biphenyl]-3-yl]-4(3H)-quinazolinone, 35MEW28

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About This Item

실험식(Hill 표기법):
C36H35ClN4O4
CAS Number:
1695533-44-8
Molecular Weight:
623.14
UNSPSC 코드:
12352200
NACRES:
NA.77

Quality Level

100

분석

≥98% (HPLC)

양식

powder

색상

white to beige

solubility

DMSO: 2 mg/mL, clear

저장 온도

2-8°C

SMILES string

O=C(N(C1=C(OC(C)C)C=CC(C2=CC=CC=C2)=C1)C(CN3CCN(C(COC4=CC=C(Cl)C=C4)=O)CC3)=N5)C6=C5C=CC=C6

생화학적/생리학적 작용

Erastin analog with greatly improved system xc- (SLC7A11/xCT + SLC3A2/4F2hc) inhibitory potency and ferropotosis induction efficacy
Erastin2 is an Erastin analog with greatly improved system xc- (SLC7A11/xCT + SLC3A2/4F2hc) inhibitory potency (Erastin2 IC50 = 3.5 nM/CCF-STTG1; Erastin IC50 = 200 nM/HT-1080, 140 nM/Calu-1; Glu release assay) and ferropotosis induction efficacy (HT-1080 EC50 = 150 nM/Erastin2 vs. 1.2 μM/Erastin).

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

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시험 성적서(COA)

Lot/Batch Number

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How cancer cells respond to nutrient deprivation remains poorly understood. In certain cancer cells, deprivation of cystine induces a non-apoptotic, iron-dependent form of cell death termed ferroptosis. Recent evidence suggests that ferroptosis sensitivity may be modulated by the stress-responsive transcription

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