SML1552

Tipiracil hydrochloride

≥98% (HPLC)

• 동의어(들): 5-Chloro-6-[(2-imino-1-pyrrolidinyl)methyl]-2,4(1H,3H)-pyrimidinedione hydrochloride, TPI hydrochloride
• 실험식(Hill 표기법): C₉H₁₁ClN₄O₂ · HCl
• CAS Number: 183204-72-0
• Molecular Weight: 279.12
• MDL number: MFCD01571384
• UNSPSC 코드: 12352200
• PubChem Substance ID: 329825960
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥98% (HPLC)
• 양식: powder
• 저장 조건: desiccated
• 색상: white to beige
• solubility: H₂O: 5 mg/mL, clear (warmed)
• 저장 온도: 2-8°C
• SMILES string: [H]Cl.ClC1=C(CN2C(CCC2)=N)NC(NC1=O)=O
• InChI: 1S/C9H11ClN4O2.ClH/c10-7-5(12-9(16)13-8(7)15)4-14-3-1-2-6(14)11;/h11H,1-4H2,(H2,12,13,15,16);1H
• InChI key: KGHYQYACJRXCAT-UHFFFAOYSA-N
• 유전자 정보: human ... TYMP(1890)

설명

생화학적/생리학적 작용

Tipiracil is an inhibitor of thymidine phosphorylase.

Tipiracil is an inhibitor of thymidine phosphorylase. Tipiracil is used in combination with trifluridine as TAS-102 for the treatment of refractory metastatic colorectal cancer. Tipiracil increases the bioavailability of trifluridine by blocking the enzyme that would otherwise protect the tumors by metabolizing trifluridine.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable