SML1509

MK6-83

≥98% (HPLC)

• 동의어(들): 5-Methyl-N-[2-(1-piperidinyl)phenyl]-2-thiophenesulfonamide
• 실험식(Hill 표기법): C₁₆H₂₀N₂O₂S₂
• CAS Number: 1062271-24-2
• Molecular Weight: 336.47
• UNSPSC 코드: 12352200
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥98% (HPLC)
• 형태: powder
• 색상: white to brown
• solubility: DMSO: 5 mg/mL, clear (warmed)
• 저장 온도: 2-8°C
• InChI: 1S/C16H20N2O2S2/c1-13-9-10-16(21-13)22(19,20)17-14-7-3-4-8-15(14)18-11-5-2-6-12-18/h3-4,7-10,17H,2,5-6,11-12H2,1H3
• InChI key: IRGYSXZCDAWOOC-UHFFFAOYSA-N

설명

생화학적/생리학적 작용

MK6-83 is a potent activator of wild type and mutant variants F465L and F408D of TRPML1 channel. MK6-83 weakly activates TRPML mutants R403C or V446L. MK6-83 restores channel function and rescue disease associated abnormalities in mucolipidosis type IV (MLIV) patient cells.

MK6-83 is known to stimulate caspase-3-dependent apoptosis. It can also decrease the viability of cells.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable