SML0627
ML-SA1
≥95% (HPLC), powder, TRPML channel agonist
동의어(들):
1-[(1,3-Dihydro-1,3-dioxo-2H-isoindol-2-yl)acetyl]-1,2,3,4-tetrahydro-2,2,4-trimethyl-quinoline, 2-(2-Oxo-2-(2,2,4-trimethyl-3,4-dihydroquinolin-1(2H)-yl)ethyl)isoindoline-1,3-dione, Mucolipin Synthetic Agonist 1
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모든 사진(1)
About This Item
추천 제품
제품명
ML-SA1, ≥95% (HPLC)
Quality Level
분석
≥95% (HPLC)
양식
powder
색상
white to beige
solubility
DMSO: 5 mg/mL, clear (warmed)
저장 온도
2-8°C
InChI
1S/C22H22N2O3/c1-14-12-22(2,3)24(18-11-7-6-8-15(14)18)19(25)13-23-20(26)16-9-4-5-10-17(16)21(23)27/h4-11,14H,12-13H2,1-3H3
InChI key
KDDHBJICVBONAX-UHFFFAOYSA-N
애플리케이션
ML-SA1 has been used as a transient receptor potential cation channel mucolipin 1 (TRPML1/ML1) agonist.
생화학적/생리학적 작용
ML-SA1 is a potent and selective cell permeable agonist of lysosomal mucolipin transient receptor potential channels (TRPML) 1, 2, 3 that significantly increases [Ca2+]cyt in HEK293 cells stably- or transiently-expressing mutant TRPML1 channels ML1-4A.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
Gastric acid secretion from parietal cells is mediated by a Ca2+ efflux channel in the tubulovesicle.
Sahoo N, et al.
Developmental Cell, 41(3), 262-273 (2017)
Mehran Najibi et al.
Autophagy, 1-18 (2021-04-06)
Macrophage activation in the presence of bacterial cells and molecules entails complex programs of gene expression. How such triggers elicit specific gene expression programs is incompletely understood. We previously discovered that TFEB (transcription factor EB) is a key contributor to
Lalit Pukhrambam Singh et al.
Diseases (Basel, Switzerland), 9(4) (2021-12-24)
Chronic hyperglycemia-induced thioredoxin-interacting protein (TXNIP) expression, associated oxidative/nitrosative stress (ROS/RNS), and mitochondrial dysfunction play critical roles in the etiology of diabetic retinopathy (DR). However, there is no effective drug treatment to prevent or slow down the progression of DR. The
Wei Xiong Siow et al.
Journal of cell science, 135(6) (2022-03-12)
Liver cancers, including hepatocellular carcinoma (HCC), are the second leading cause of cancer death worldwide, and novel therapeutic strategies are still highly needed. Recently, the endolysosomal cation channel TRPML1 (also known as MCOLN1) has gained focus in cancer research because
Simona Ida Scorza et al.
International journal of molecular sciences, 24(2) (2023-01-22)
Lysosomes are acidic Ca2+ storage organelles that actively generate local Ca2+ signaling events to regulate a plethora of cell functions. Here, we characterized lysosomal Ca2+ signals in mouse renal collecting duct (CD) cells and we assessed their putative role in
문서
We offer many products related to transient receptor potential channels for your research needs.
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