SML1192

SB290157 trifluoroacetate salt

≥97% (HPLC)

• 동의어(들): N2-[2-(2,2-Diphenylethoxy)acetyl]-L-arginine trifluoroacetate salt, SB 290157 trifluoroacetate salt
• 실험식(Hill 표기법): C₂₂H₂₈N₄O₄ · CF₃CO₂H
• CAS Number: 1140525-25-2
• Molecular Weight: 526.51
• UNSPSC 코드: 12352200
• PubChem Substance ID: 329825711
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥97% (HPLC)
• 형태: powder
• 광학 활성: [α]/D +1.5 to +5°, c = 1.0 in DMSO
• 저장 조건: desiccated
• 색상: white to beige
• solubility: DMSO: 10 mg/mL, clear
• 저장 온도: −20°C
• SMILES string: NC(NCCC[C@@H](C(O)=O)NC(COCC(C1=CC=CC=C1)C2=CC=CC=C2)=O)=N.FC(F)(C(O)=O)F
• InChI: 1S/C22H28N4O4.C2HF3O2/c23-22(24)25-13-7-12-19(21(28)29)26-20(27)15-30-14-18(16-8-3-1-4-9-16)17-10-5-2-6-11-17;3-2(4,5)1(6)7/h1-6,8-11,18-19H,7,12-15H2,(H,26,27)(H,28,29)(H4,23,24,25);(H,6,7)/t19-;/m0./s1
• InChI key: ZJRMPPVJAQWGEG-FYZYNONXSA-N

설명

생화학적/생리학적 작용

SB290157 is a selective antagonist of complement anaphylatoxin C3a receptor, a 74 amino acid proinflammatory peptide that is a potent chemotaxin for eosinophils, macrophages and mast cells, and has recently been found to be involved in nonimmunological roles in osteoblast differentiation, angiogenesis, and lipid metabolism. SB290157 is selective for C3aR over C5aR or other chemotactic GPCRs with an IC50 of 200 nM. It effectively blocks C3aR in humans, rat, guinea pig, and mouse.SB290157 was found to inhibit diet-induced obesity, metabolic dysfunction, and adipocyte signaling, in addition to inhibiting macrophage signaling.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable