SML1162

5-Fluoro-1-propargyl-uracil

≥98% (HPLC)

• 동의어(들): 1-Propargyl-5-fluorouracil, 5-Fluoro-1-(2-propyn-1-yl)-2,4(1H,3H)-pyrimidinedione
• 실험식(Hill 표기법): C₇H₅FN₂O₂
• CAS Number: 69849-33-8
• Molecular Weight: 168.13
• MDL number: MFCD18364451
• UNSPSC 코드: 12352200
• PubChem Substance ID: 329825692
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥98% (HPLC)
• 양식: powder
• 색상: white to beige
• solubility: H₂O: 1 mg/mL, clear (warmed)
• 저장 온도: 2-8°C
• SMILES string: O=C1C(F)=CN(CC#C)C(N1)=O
• InChI: 1S/C7H5FN2O2/c1-2-3-10-4-5(8)6(11)9-7(10)12/h1,4H,3H2,(H,9,11,12)
• InChI key: GMCOGJQJFDQZCP-UHFFFAOYSA-N

설명

생화학적/생리학적 작용

5-Fluoro-1-propargyl-uracil is a biologically inert precursor, a prodrug that can be bioorthogonally activated to 5-fluorouracil iside a tumor that has a previously implanted palladium catalyst. Preliminary tests with pancreatic and colorectal cancer cells resulted in the death of than 80% of the malignant cells.

5-Fluoro-1-propargyl-uracil is a biologically inert precursor, a prodrug that can be bioorthogonally activated to 5-fluorouracil.

특징 및 장점

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안전성 정보

• 픽토그램: GHS07
• 신호어: Warning
• 유해 및 위험 성명서: H302
• 예방조치 성명서: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable