SML0964

KNK437

≥98% (HPLC)

• 동의어(들): 3-(1,3-Benzodioxol-5-ylmethylene)-2-oxo-1-pyrrolidinecarboxaldehyde
• 실험식(Hill 표기법): C₁₃H₁₁NO₄
• CAS Number: 218924-25-5
• Molecular Weight: 245.23
• UNSPSC 코드: 12352200
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥98% (HPLC)
• 양식: powder
• 색상: white to beige
• solubility: DMSO: 5 mg/mL, clear (warmed)
• 저장 온도: room temp

설명

애플리케이션

KNK437 has been used:

• as a heat shock factor 1 (HSF1) inhibitor to study its effects on the inhibition of viability and apoptosis activation in chemoresistant mice cells
• as an HSF1 inhibitor to study its effects on viability and apoptosis of colorectal cancer cells
• as a heat shock protein 70 (HSP70) inhibitor to study its effects on glutamine-induced HSP70 and inflammatory mediator release

생화학적/생리학적 작용

KNK437 inhibits the accumulation of heat shock proteins (including hsp -27, -40, -70, -72 and -105). KNK437 inhibits thermotolerance in cells with greater potency than quercetin.

KNK437 is a benzylidene lactam compound.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable