SML0494

VU0361737

≥98% (HPLC)

• 동의어(들): CID-44191096, ML128, N-(4-Chloro-3-methoxyphenyl)-2-pyridinecarboxamide
• 실험식(Hill 표기법): C₁₃H₁₁ClN₂O₂
• CAS Number: 1161205-04-4
• Molecular Weight: 262.69
• MDL number: MFCD16618402
• UNSPSC 코드: 12352200
• PubChem Substance ID: 329825444
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥98% (HPLC)
• 양식: film
• 색상: white
• solubility: DMSO: 15 mg/mL (clear solution)
• 저장 온도: 2-8°C
• SMILES string: COc1cc(NC(=O)c2ccccn2)ccc1Cl
• InChI: 1S/C13H11ClN2O2/c1-18-12-8-9(5-6-10(12)14)16-13(17)11-4-2-3-7-15-11/h2-8H,1H3,(H,16,17)
• InChI key: ARYUXFNGXHNNDM-UHFFFAOYSA-N

설명

생화학적/생리학적 작용

VU0361737 is an mGluR4-specific positive allosteric modulator (PAM) with greater than 50 fold selectivity over other mGluR subtypes. The EC₅₀ values for human and rat mGlu4 are 240 and 110 nM, respectively, compared to greater than 10 mM for all other mGluRs.

VU0361737 is an mGluR4-specific positive allosteric modulator (PAM).

특징 및 장점

This compound is featured on the Glutamate Receptors (G Protein Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

안전성 정보

• 픽토그램: GHS07
• 신호어: Warning
• 유해 및 위험 성명서: H302,H319
• 예방조치 성명서: P264 - P280 - P301 + P312 - P305 + P351 + P338 - P337 + P313 - P501
• Hazard Classifications: Acute Tox. 4 Oral - Eye Irrit. 2
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable