SML0474

(S)-Duloxetine hydrochloride

≥98% (HPLC)

• 동의어(들): (γS)-N-Methyl-γ-(1-naphthalenyloxy)-2-thiophenepropanamine hydrochloride, (+)-(S)-N-Methyl-γ-(1-naphthyloxy)-2-thiophenepropylamine hydrochloride, (+)-N-Methyl-3-(1-naphthalenyloxy)-3-(2-thienyl)propanamine hydrochloride, LY-248686 hydrochloride
• 실험식(Hill 표기법): C₁₈H₁₉NOS · HCl
• CAS Number: 136434-34-9
• Molecular Weight: 333.88
• MDL number: MFCD06407958
• UNSPSC 코드: 12352200
• PubChem Substance ID: 329825429
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥98% (HPLC)
• 양식: powder
• 광학 활성: [α]/D +116 to +125°, c = 1 in methanol
• 저장 조건: desiccated
• 색상: white to beige
• solubility: H₂O: 5 mg/mL (clear solution, warmed)
• 저장 온도: room temp
• SMILES string: Cl.CNCC[C@H](Oc1cccc2ccccc12)c3cccs3
• InChI: 1S/C18H19NOS.ClH/c1-19-12-11-17(18-10-5-13-21-18)20-16-9-4-7-14-6-2-3-8-15(14)16;/h2-10,13,17,19H,11-12H2,1H3;1H/t17-;/m0./s1
• InChI key: BFFSMCNJSOPUAY-LMOVPXPDSA-N
• 유전자 정보: human ... SLC6A2(6530) , SLC6A4(6532)

설명

일반 설명

(S)-Duloxetine hydrochloride belongs to the class of serotonin and norepinephrine reuptake inhibitors. Duloxetine is a thiophene derivative. It is used to treat stress urinary incontinence, psychiatric and metabolic disorders. It is also used for treating diabetic peripheral neuropathic pain, fibromyalgia, chronic musculoskeletal and low back pain (LBP). Duloxetine is a cytochrome P450 2D6 (CYP2D6) inhibitor.

애플리케이션

(S)-Duloxetine hydrochloride has been used as an antidepressant in rats exposed to chronic mild stress (CMS).

생화학적/생리학적 작용

Duloxetine hydrochloride is a dual serotonin/norepinephrine reuptake inhibitor (SNRI), widely used clinically as an antidepressant and anxiolytic.

Duloxetine hydrochloride is a dual serotonin/norepinephrine reuptake inhibitor (SNRI); antidepressant; anxiolytic.

특징 및 장점

This compound is featured on the Biogenic Amine Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

주의사항

air sensitive

안전성 정보

• 픽토그램: GHS07
• 신호어: Warning
• 유해 및 위험 성명서: H302
• 예방조치 성명서: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable