SML0345

A 887826

≥98% (HPLC)

• 동의어(들): 5-(4-butoxy-3-chlorophenyl)-N-[[2-(4-morpholinyl)-3-pyridinyl]methyl]-3-pyridinecarboxamide
• 실험식(Hill 표기법): C₂₆H₂₉ClN₄O₃
• CAS Number: 1266212-81-0
• Molecular Weight: 480.99
• MDL number: MFCD20926345
• UNSPSC 코드: 12352200
• PubChem Substance ID: 329825349
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥98% (HPLC)
• 형태: powder
• 색상: white to beige
• solubility: DMSO: ≥5 mg/mL
• 저장 온도: 2-8°C
• SMILES string: CCCCOc1ccc(cc1Cl)-c2cncc(c2)C(=O)NCc3cccnc3N4CCOCC4
• InChI: 1S/C26H29ClN4O3/c1-2-3-11-34-24-7-6-19(15-23(24)27)21-14-22(17-28-16-21)26(32)30-18-20-5-4-8-29-25(20)31-9-12-33-13-10-31/h4-8,14-17H,2-3,9-13,18H2,1H3,(H,30,32)
• InChI key: JPJGFWKHSMUKFO-UHFFFAOYSA-N

설명

생화학적/생리학적 작용

A-887826 is Nav1.8 channel blocker (IC₅₀ = 11 nM) that blocks TTX-resistant sodium currents in rat dorsal root ganglion in a voltage dependent fashion. Oral administration of A-887826 to rats significantly attenuated tactile allodynia in a neuropathic pain model.

안전성 정보

• 픽토그램: GHS06
• 신호어: Danger
• 유해 및 위험 성명서: H301
• 예방조치 성명서: P264 - P270 - P301 + P310 - P405 - P501
• Hazard Classifications: Acute Tox. 3 Oral
• Storage Class Code: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable