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Merck
모든 사진(1)

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SML0140

Sigma-Aldrich

BV02

≥98% (HPLC)

동의어(들):

2-(2,3-Dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)-2,3-dihydro-1,3-dioxo-1H-isoindole-5-carboxylic acid

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모든 사진(1)

About This Item

실험식(Hill 표기법):
C20H15N3O5
CAS Number:
292870-53-2
Molecular Weight:
377.35
MDL number:
MFCD00356631
UNSPSC 코드:
12352200
PubChem Substance ID:
329825188
NACRES:
NA.77

설명

The structure of BV02 differs slightly from the published form, but has been internally verified by Sigma-Aldrich quality control.

Quality Level

100

분석

≥98% (HPLC)

형태

powder

색상

white to off-white

solubility

DMSO: >5 mg/mL

저장 온도

room temp

SMILES string

CN1N(c2ccccc2)C(=O)C(N3C(=O)c4ccc(cc4C3=O)C(O)=O)=C1C

InChI

1S/C20H15N3O5/c1-11-16(19(26)23(21(11)2)13-6-4-3-5-7-13)22-17(24)14-9-8-12(20(27)28)10-15(14)18(22)25/h3-10H,1-2H3,(H,27,28)

InChI key

ZFYSDSINNOLWGO-UHFFFAOYSA-N

애플리케이션

BV02 has been used to study the effects of 14-3-3σ on P-glycoprotein and pregnane X receptor protein xpression. It has also been used as a control in studying BAP1 (BRCA1 (breast cancer gene)-associated protein 1) inducing cell death via interaction with 14-3-3 in neuroblastoma.
BV02, an inhibitor of the 14-3-3 scaffolding protein docking sites, may be used to study the roles and functions of 14-3-3 scaffolding proteins in signaling pathways involved in the cell cycle, and processes such as apoptosis, stress response, and malignant cell transformation.

생화학적/생리학적 작용

BV02 is an inhibitor of the 14-3-3 scaffolding proteins docking site. BV02 promotes the apoptotic death of cells expressing either wt Bcr-Abl construct or T315I mutation. It induces apoptosis by c-Abl release from 14-3-3? and re-location to nuclear compartment and at mitochondrial membranes.

픽토그램

Environment
GHS09

신호어

Warning

유해 및 위험 성명서

H400

예방조치 성명서

P273 - P391 - P501

Hazard Classifications

Aquatic Acute 1

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

시험 성적서(COA)

제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.

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Role of 14-3-3 sigma in over-expression of P-gp by rifampin and paclitaxel stimulation through interaction with PXR
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Cellular Signalling, 31, 124-134 (2017)
BAP1 induces cell death via interaction with 14-3-3 in neuroblastoma
Sime W, et al.
Cell Death & Disease, 9(5), 458-458 (2018)
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