SMB01055

Colladin

≥90% (LC/MS-ELSD)

• 동의어(들): Coladin
• 실험식(Hill 표기법): C₂₆H₃₂O₅
• CAS Number: 28691-96-5
• Molecular Weight: 424.53
• UNSPSC 코드: 12352205
• NACRES: NA.25

속성

• 생물학적 소스: plant
• 분석: ≥90% (LC/MS-ELSD)
• 형태: solid
• 분자량: 424.53
• solubility: water: slightly soluble
• 응용 분야: metabolomics; vitamins, nutraceuticals, and natural products
• 저장 온도: −20°C

설명

일반 설명

Colladin, a sesquiterpenoid coumarin, is a natural product commonly available from Ferula Sp. (F. arrigonii, F. vesceritensis, F. campestris and F. sinaica) plants. Existing research suggests that this plant-derived metabolite exerts various biological activities, including anticancer, neuroprotective, and antiglaucoma properties.

애플리케이션

It is a natural product derived from plant source that finds application in compound screening libraries, metabolomics, phytochemical, and pharmaceutical research.

생화학적/생리학적 작용

According to the existing research, Coladin exhibited notable anti-cancer properties by substantially reducing cell proliferation and mitochondrial dehydrogenase activity in mouse B16F1 melanoma cells. These effects induced apoptosis through mechanisms involving decreased mitochondrial membrane potential and mitochondrial respiratory rate, underscoring its potential as a natural anti-cancer agent. Isolated from the roots of Ferulago campestris, coladin, along with other compounds such as umbelliprenin and epielmanticine, displayed inhibitory activity against Acetylcholinesterase (AChE) with an IC50 of 0.1 mM, suggesting its potential application in the treatment of neurological disorders like Alzheimer′s disease. Coladin, identified as one of the constituents in Heptaptera triquetra fruit, exhibited remarkable inhibitory activity against acetylcholinesterase (AChE), human carbonic anhydrase isoenzyme (hCA) I, and hCA II, with IC50 values of 8.25 nM, 28.90 nM, and 43.31 nM, respectively. This highlights its potential in the development of phytotherapeutics for conditions like Alzheimer′s disease (AD) and glaucoma.

특징 및 장점

• High quality compound suitable for multiple research applications
• Compatible with HPLC and mass spectrometry techniques

기타 정보

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안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable