SMB00802
Bavachin
from Psoralea coryfolia, ≥97% (HPLC)
동의어(들):
(2S)-2,3-Dihydro-7-hydroxy-2-(4-hydroxyphenyl)-6-(3-methyl-2-butenyl)-4H-1-benzopyran-4-one, 4′,7-Dihydroxy 6-(3-methyl 2-butenyl)flavanone, Corylifolin
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모든 사진(1)
About This Item
실험식(Hill 표기법):
C20H20O4
CAS Number:
Molecular Weight:
324.37
MDL number:
UNSPSC 코드:
12352205
NACRES:
NA.28
추천 제품
분석
≥97% (HPLC)
양식
powder
응용 분야
metabolomics
vitamins, nutraceuticals, and natural products
저장 온도
−20°C
SMILES string
O1C(CC(=O)c3c1cc(c(c3)CC=C(C)C)O)c2ccc(cc2)O
InChI
1S/C20H20O4/c1-12(2)3-4-14-9-16-18(23)11-19(24-20(16)10-17(14)22)13-5-7-15(21)8-6-13/h3,5-10,19,21-22H,4,11H2,1-2H3
InChI key
OAUREGNZECGNQS-UHFFFAOYSA-N
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생화학적/생리학적 작용
Bavachin is a flavonoid isolated from seeds of Psoralea corylifolia. It is a phytoestrogen that activates ERα and ERβ (EC50s = 320 and 680 nM, respectively), stimulates osteoblast proliferation and differentiation, and prevents bone loss following ovariectomy in rats.
Bavachin is an inhibitor of acyl coenzyme A: cholesterol acyltransferase (ACAT). The IC50 value of bavachin was reported to be 86.0 μM in ACAT assay system using rat liver microsome.
Bavachin is also reported to increase insulin-induced glucose uptake by differentiated adipocytes and myoblasts.
Bavachin is an inhibitor of acyl coenzyme A: cholesterol acyltransferase (ACAT). The IC50 value of bavachin was reported to be 86.0 μM in ACAT assay system using rat liver microsome.
Bavachin is also reported to increase insulin-induced glucose uptake by differentiated adipocytes and myoblasts.
물리적 특성
Bavachin is soluble in DMSO at 30 mg/mL. Bavachin is not water soluble.
신호어
Warning
유해 및 위험 성명서
Hazard Classifications
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
Jung Ho Choi et al.
Archives of pharmacal research, 31(11), 1419-1423 (2008-11-22)
Acyl-coenzyme A: cholesterol acyltransferase (ACAT) catalyzes cholesterol esterification and plays important roles in intestinal absorption of cholesterol, hepatic production of lipoproteins and accumulation of cholesteryl ester within macrophages and smooth muscle cells. Ethanol extract of Psoralea corylifolia showed a significant
Joonwoo Park et al.
Biomolecules & therapeutics, 20(2), 183-188 (2012-03-01)
In this study, we examined the estrogenic activity of bavachin, a component of Psoralea corylifolia that has been used as a traditional medicine in Asia. Bavachin was purified from ethanolic extract of Psoralea corylifolia and characterized its estrogenic activity by
Hyejin Lee et al.
International journal of molecular sciences, 17(4), 527-527 (2016-04-14)
The fruit of Psoralea corylifolia L. (Fabaceae) (PC), known as "Bo-Gol-Zhee" in Korea has been used as traditional medicine. Ethanol and aqueous extracts of PC have an anti-hyperglycemic effect by increasing plasma insulin levels and decreasing blood glucose and total
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