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Merck
모든 사진(1)

주요 문서

SCP0157

Sigma-Aldrich

Gly-Arg-Gly-Asp-Ser-Pro (GRGDSP)

동의어(들):

GRGDSP Peptide, RGD Peptide

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모든 사진(1)

About This Item

실험식(Hill 표기법):
C22H37N9O10
Molecular Weight:
587.58
UNSPSC 코드:
12352209
NACRES:
NA.32

분석

≥95% (HPLC)

양식

lyophilized

구성

Peptide Content, ≥60%

저장 조건

protect from light

저장 온도

−20°C

Amino Acid Sequence

Gly-Arg-Gly-Asp-Ser-Pro

일반 설명

Gly-Arg-Gly-Asp-Ser-Pro (GRGDSP) is a bioactive molecule/peptide derived from fibronectin.

애플리케이션

Gly-Arg-Gly-Asp-Ser-Pro (GRGDSP) has been used:
  • in coating well plate to monitor cell attachment by crystal violet staining
  • to treat baby hamster kidney (BHK-21) cells to study the role of Arg-Gly-Asp (RGD) motif in the replication of Japanese encephalitis virus (JEV)
  • to block RGD-dependent integrins or integrin signaling in INA-6 cells
  • to study the role of the RGD-binding integrins in Gal-3-mediated cell adhesion

생화학적/생리학적 작용

Gly-Arg-Gly-Asp-Ser-Pro (GRGDSP) can stimulate endothelialization by modifying the surface of cardiovascular implants. The major cell- binding domain of GRGDSP helps to promote cell adhesion on a wide range of substrates.
Gly-Arg-Gly-Asp-Ser-Pro (GRGDSP) is used as a soluble integrin-blocking RGD-based peptide. GRGDSP is used widely together with other RGD peptides in integrin research.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

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시험 성적서(COA)

Lot/Batch Number
CM0439

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문서 라이브러리 방문

Shyam Patel et al.
Journal of biomedical materials research. Part A, 83(2), 423-433 (2007-04-25)
Vascular endothelium plays an important role in preventing thrombogenesis. Bioactive molecules such as fibronectin-derived peptide Gly-Arg-Gly-Asp-Ser-Pro (GRGDSP) can be used to modify the surface of cardiovascular implants such as vascular grafts to promote endothelialization. Here we conjugated GRGDSP peptide to
Ines Lauria et al.
Acta biomaterialia, 62, 317-327 (2017-09-03)
Bionanoparticles based on filamentous phages or flexuous viruses are interesting candidates for meeting the challenges of tailoring biomineralization in hydrogel-based bone tissue substitutes. We hypothesized that hydroxyapatite crystal nucleation and matrix mineralization can be significantly increased by mineralization-inducing (MIP) and
Julia Dotterweich et al.
Cell communication and signaling : CCS, 12, 36-36 (2014-06-27)
CCN family member 1 (CCN1), also known as cysteine-rich angiogenic inducer 61 (CYR61), belongs to the extracellular matrix-associated CCN protein family. The diverse functions of these proteins include regulation of cell migration, adhesion, proliferation, differentiation and survival/apoptosis, induction of angiogenesis
Antonín Sedlář et al.
International journal of molecular sciences, 22(10) (2021-06-03)
Galectin-3 (Gal-3) is a β-galactoside-binding protein that influences various cell functions, including cell adhesion. We focused on the role of Gal-3 as an extracellular ligand mediating cell-matrix adhesion. We used human adipose tissue-derived stem cells and human umbilical vein endothelial

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