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Merck
모든 사진(1)

주요 문서

SCP0036

Sigma-Aldrich

Amyloid β 13-16 human

≥95% (HPLC)

동의어(들):

HHQK

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모든 사진(1)

About This Item

실험식(Hill 표기법):
C23H36N10O6
Molecular Weight:
548.60
UNSPSC 코드:
12352200
NACRES:
NA.32

분석

≥95% (HPLC)

양식

lyophilized

구성

Peptide Content, ≥45%

저장 조건

protect from light

저장 온도

−20°C

관련 카테고리

Amino Acid Sequence

His-His-Gln-Lys

애플리케이션

Amyloid β (Aβ) refers to peptides derived from Amyloid precursor protein that vary in length from 36-43 amino acids. Aβ(s) peptides, their peptide fragments and mutated fragments are used to study a wide range of metabolic and regulatory functions including activation of kinases, regulation of cholesterol transport, function as a transcription factor, and regulators of inflammation. Aβ(s) peptides and their peptide fragments are also used to study oxidative stress, metal binding and mechanisms of protein cross-linking in the context of diseases such as Alzheimer′s disease and neurodegeneration. HHQK is a studied as a unique target site for inhibition of amyloid fibril formation and proteoglycan binding.

Storage Class Code

11 - Combustible Solids

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

가장 최신 버전 중 하나를 선택하세요:

시험 성적서(COA)

Lot/Batch Number
BD0248

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COA 검색

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문서 라이브러리 방문

Toshio Ariga et al.
Journal of neuroscience research, 88(11), 2303-2315 (2010-07-14)
The extracellular accumulation of amyloid beta proteins (Abetas) in neuritic plaques is one of the hallmarks of Alzheimer's disease (AD). The binding of Abetas to extracellular membranes (ECMs) is a critical step in developing AD. Abetas bind to many biomolecules
J McLaurin et al.
European journal of biochemistry, 267(21), 6353-6361 (2000-10-13)
One of the major clinical features of Alzheimer's disease is the presence of extracellular amyloid plaques that are associated with glycosaminoglycan-containing proteoglycans. It has been proposed that proteoglycans and glycosaminoglycans facilitate amyloid fibril formation and/or stabilize these aggregates. Characterization of
D Giulian et al.
The Journal of biological chemistry, 273(45), 29719-29726 (1998-10-29)
The beta-amyloid peptide 1-42 (Abeta1-42), a major component of neuritic and core plaques found in Alzheimer's disease, activates microglia to kill neurons. Selective modifications of amino acids near the N terminus of Abeta showed that residues 13-16, the HHQK domain

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