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Merck
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Key Documents

SBR00020

Sigma-Aldrich

Zearalenone Ready Made Solution

1 mg/mL in DMSO

동의어(들):

(3S,11E)-3,4,5,6,9,10-hexahydro-14,16-dihydroxy-3-methyl-,1H-2-benzoxacyclotetradecin-1,7(8H)-dione, F-2 toxin

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About This Item

실험식(Hill 표기법):
C18H22O5
CAS Number:
Molecular Weight:
318.36
MDL number:
UNSPSC 코드:
12352200

형태

liquid

농도

1 mg/mL in DMSO

저장 온도

−20°C

InChI

1S/C18H22O5/c1-12-6-5-9-14(19)8-4-2-3-7-13-10-15(20)11-16(21)17(13)18(22)23-12/h3,7,10-12,20-21H,2,4-6,8-9H2,1H3/b7-3+/t12-/m0/s1

InChI key

MBMQEIFVQACCCH-QBODLPLBSA-N

생화학적/생리학적 작용

Zearalenone, a fungal mycotoxin produced by Fusarium graminearum, binds estrogen receptor (ER) causing conformational alteration to the receptor. Zearalenone is a common contaminant in cereal grain used for animal and human food. It exerts an estrogenic activity that modulates/disrupts endocrine function in animals and possibly humans. Furthermore, zearalenone was found to act as an immune-toxic compound, which can cause food consumption reduction in rats.

Storage Class Code

10 - Combustible liquids

WGK

WGK 2

Flash Point (°F)

188.6 °F - closed cup

Flash Point (°C)

87 °C - closed cup


시험 성적서(COA)

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문서 라이브러리 방문

이미 열람한 고객

Karolina Kowalska et al.
Environmental toxicology and pharmacology, 48, 141-149 (2016-10-25)
Zearalenone (ZEA), a fungal mycotoxin, is present in a wide range of human foods. Many animal studies have found ZEA to possess a disruptive effect on the hormonal balance, mainly due to its similarity to naturally-occurring estrogens. With increasing consciousness
Isis M Hueza et al.
Toxins, 6(3), 1080-1095 (2014-03-19)
The aim of this study was to assess the toxic effects of zearalenone (ZEA) on the immune function. Ovariectomised rats were treated daily by gavage with 3.0 mg/kg of ZEA for 28 days. Body weight gain, food consumption, haemotological parameters
Hitomi Takemura et al.
The Journal of steroid biochemistry and molecular biology, 103(2), 170-177 (2006-11-14)
In the present study, we compared the estrogenic activity of zearalenone (ZEN) and zeranol (ZOL) by determining their relative receptor binding affinities for human ERalpha and ERbeta and also by determining their uterotropic activity in ovariectomized female mice. ZOL displayed

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