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SAE0062

Sigma-Aldrich

Lipodisq®

Styrene:Maleic Anhydride Copolymer 2:1, Pre-hydrolyzed

동의어(들):

Lipodisq Reagent, Lipodisq Solution

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About This Item

UNSPSC 코드:
12352200
NACRES:
NA.25

Quality Level

200

저장 온도

room temp

일반 설명

Lipodisq nanoparticles are usually made up of styrene maleic acid (SMA) copolymer and phospholipids. It has almost similar structure to that of nanodiscs. Lipodisq nanoparticles are considered as a good membrane mimetic system for the structural studies of membrane proteins.

애플리케이션

Lipodisq reagents are novel polymers derived from styrene and maleic acid. Lipodisq polymers are capable of forming nanosized lipid-based discoidal particles capable of incorporating membrane proteins. The Lipodisq technology can solubilize commonly used lipids such as dimyristoylphosphatidylcholine (DMPC) without the use of detergents. Lipodisqs typically have a diameter of 9-10 nm at pH 7.4.

The Lipodisq technology can solubilize commonly used lipids such as dimyristoylphosphatidylcholine (DMPC) without the use of detergents.

Functional pH range: 5.5 - 8.0

생화학적/생리학적 작용

Lipodisq nanoparticles are considered as a good membrane mimetic system for the structural studies of membrane proteins.

포장

100, 500 mg in poly bottle

법적 정보

Lipodisq is a registered trademark of Malvern Cosmeceutics Limited

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

시험 성적서(COA)

제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.

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문서 라이브러리에서 최근에 구매한 제품에 대한 문서를 찾아보세요.

문서 라이브러리 방문

Characterization of the structure of lipodisq nanoparticles in the presence of KCNE1 by dynamic light scattering and transmission electron microscopy
Zhang R, et al.
Chemistry and Physics of Lipids, 203, 19-23 (2017)
Characterization of KCNE1 inside lipodisq nanoparticles for EPR spectroscopic studies of membrane proteins
Sahu I D, et al.
The Journal of Physical Chemistry B, 121(21), 5312-5321 (2017)
Juan Francisco Bada Juarez et al.
Biochimica et biophysica acta. Biomembranes, 1862(3), 183152-183152 (2019-12-18)
Dopamine receptors (DRs) are class A G-Protein Coupled Receptors (GPCRs) prevalent in the central nervous system (CNS). These receptors mediate physiological functions ranging from voluntary movement and reward recognition to hormonal regulation and hypertension. Drugs targeting dopaminergic neurotransmission have been
Juan Francisco Bada Juarez et al.
Chemistry and physics of lipids, 221, 167-175 (2019-04-04)
Nanoparticles assembled with poly(styrene-maleic acid) copolymers, identified in the literature as Lipodisq, SMALPs or Native Nanodisc, are routinely used as membrane mimetics to stabilise protein structures in their native conformation. To date, transmembrane proteins of varying complexity (up to 8

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