추천 제품
생물학적 소스
mouse
결합
unconjugated
항체 형태
ascites fluid
항체 생산 유형
primary antibodies
클론
2A11G9, monoclonal
종 반응성
mouse, human
기술
direct ELISA: 1:10,000
immunohistochemistry: 1:200-1:1,000
indirect immunofluorescence: 1:200-1:1,000
western blot: 1:500-1:2,000
동형
IgG1
NCBI 수납 번호
UniProt 수납 번호
배송 상태
wet ice
저장 온도
−20°C
타겟 번역 후 변형
unmodified
유전자 정보
human ... Foxp3(50943)
일반 설명
Forkhead box P3 (FOXP3) is located on human chromosome Xp11.23-Xq13.3. FOXP3 is a putative DNA-binding protein and is a member of the forkhead family. The protein is mainly expressed in the CD4+CD25+ regulatory T-cell subsets.
면역원
Purified recombinant fragment of human Foxp3 expressed in E.coli.
Mouse monoclonal antibody raised against Foxp3
Mouse monoclonal antibody raised against Foxp3
애플리케이션
Monoclonal Anti-FOXP3 antibody has been used in immunohistochemistry (IHC).
생화학적/생리학적 작용
Forkhead box P3 (FOXP3) plays an essential role in the development of CD4+CD25+ regulatory T cells and regulates immune homeostasis. It also acts as a transcriptional repressor. Polyadenylation signal mutation of the gene leads to immune dysregulation, polyendocrinopathy, enteropathy and X-linked inheritance (IPEX). Abnormalities in the gene expression are also associated with the pathogenesis of autism spectrum disorders (ASD) and unexplained recurrent spontaneous abortion (URSA).
물리적 형태
Ascitic fluid containing 0.03% sodium azide.
면책조항
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
가장 최신 버전 중 하나를 선택하세요:
Correlation between protein expression of FOXP3 and level of FOXP3 promoter methylation in recurrent spontaneous abortion
Hou Wenhui, et al.
Journal of Obstetrics and Gynaecology : The Journal of the Institute of Obstetrics and Gynaecology, 42(11), 1439-1444 (2016)
FOXP3 gene variations and susceptibility to autism: a case-control study
Safari, et al.
Gene, 596(6), 119-122 (2017)
Role of PIM2 in allergic asthma
Du Wei, et al.
Molecular Medicine Reports, 16(5), 7504-7512 (2017)
C L Bennett et al.
Immunogenetics, 53(6), 435-439 (2001-10-31)
The mouse scurfy gene, Foxp3, and its human orthologue, FOXP3, which maps to Xp11.23-Xq13.3, were recently identified by positional cloning. Point mutations and microdeletions of the FOXP3 gene were found in the affected members of eight of nine families with
Eleonora Gambineri et al.
Current opinion in rheumatology, 15(4), 430-435 (2003-06-24)
Immune dysregulation, polyendocrinopathy, enteropathy, and X-linked inheritance (IPEX) is one of a group of clinical syndromes that present with multisystem autoimmune disease suggesting a phenotype of immune dysregulation. Clinically, IPEX manifests most commonly with diarrhea, insulin-dependent diabetes mellitus, thyroid disorders
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