SAB5201266

Monoclonal Anti-Pink1 antibody produced in mouse

clone S4-15, purified immunoglobulin

• 동의어(들): Anti- BRPK, Anti-PTEN-induced putative kinase protein 1, Anti-Parkinson disease (autosomal recessive) 6
• UNSPSC 코드: 12352203
• NACRES: NA.41

속성

• 생물학적 소스: mouse
• Quality Level: 100
• 결합: unconjugated
• 항체 형태: purified immunoglobulin
• 항체 생산 유형: primary antibodies
• 클론: S4-15, monoclonal
• 형태: buffered aqueous solution
• 분자량: antigen predicted mol wt 50 kDa
• 종 반응성: rat, mouse, human
• 농도: 1 mg/mL
• 기술: immunocytochemistry: suitable; immunohistochemistry: suitable; western blot: suitable
• 동형: IgG1
• NCBI 수납 번호: NP_115785.1
• UniProt 수납 번호: Q9BXM7
• 배송 상태: wet ice
• 저장 온도: −20°C
• 타겟 번역 후 변형: unmodified
• 유전자 정보: human ... PINK1(65018)

설명

일반 설명

PTEN induced kinase 1 (PINK1), a serine/threonine kinase localizes to mitochondria. It comprises an N-terminal mitochondrial targeting sequence, C-terminal kinase domain, and a transmembrane anchor region. The PINK1 gene is mapped to human chromosome 1p36.12.

면역원

Fusion protein amino acids 112-496 (cytoplasmic C-terminus) of human PINK1. 82% identical to rat and 81% identical to mouse. >30% identity with DMPK.

생화학적/생리학적 작용

PTEN induced kinase 1 (PINK1) participates in mitochondrial component biogenesis. It mediates the translation of mitochondrial respiratory chain subunits encoding nuclear mRNAs. The kinase domain region of PINK1 gene harbors most of the mutations. Mutations in the PINK1 gene are implicated in early-onset Parkinson′s disease (PD). The accumulation of PINK1 in dysfunctional mitochondria marks them for degradation. PINK1 is also implicated in the pathophysiology of cancer, diabetes, and pulmonary fibrosis.

특징 및 장점

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

물리적 형태

PBS pH 7.4, 50% glycerol, 0.1% sodium azide

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable